Results 51 to 60 of about 326,618 (217)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Beyond the 15-minute city: Methodological lessons for proximity-based planning from two English case studies

Transportation Research Interdisciplinary Perspectives
The 15-minute city (15MC) popularises an older idea: that everyday destinations should be within a short, walkable or cyclable distance. Treating that idea more broadly as proximity-based planning, this study examines two English case-studies − Toxteth ...
Alexander Nurse, Caglar Koksal, Graeme Sherriff   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mapping subcellular RNA localization with proximity labeling

Acta Biochimica et Biophysica Sinica
The subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate.
Liu Jiapeng, Zhong Binglin, Li Shuojun, Han Shuo   +3 more
doaj   +1 more source

Latency Analysis of Wireless Networks for Proximity Services in Smart Home and Building Automation: The Case of Thread

IEEE Access, 2019
Proximity service (ProSe), using the geographic location and device information by considering the proximity of mobile devices, enriches the services we use to interact with people and things around us.
Dapeng Lan, Zhibo Pang, Carlo Fischione, Yu Liu, Amir Taherkordi, Frank Eliassen   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

“You are the only other person in the world that knows that about me”: Family physician stories of proximity to patients experiencing social inequity

SSM: Qualitative Research in Health
Canadians' health outcomes are inextricably tied to social inequities. Family medicine is uniquely situated to provide care that addresses social factors through longitudinal knowledge of patients and the contexts of their lives.
Monica L. Molinaro, Katrina Shen, Chitrini Tandon, Gina Agarwal, Gabrielle Inglis, Meredith Vanstone   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Examining Cognitive and Social Proximities’ Influence on Cluster Firms’ Green Technological Innovation

SAGE Open
Green technological innovation (GTI) has the dual externalities of promoting technological advancements and facilitating environmental protection. GTI assists manufacturing clusters respond to emission reduction and environmental protection challenges ...
Mei Han, Bilin Xu
doaj   +1 more source