Results 91 to 100 of about 1,382,332 (278)

Critical Raw Materials Recovery through Bio/Hydrometallurgy from Secondary Resources

Metals, 2019
Demand for critical raw materials (CRMs) to be used in consumer products is growing rapidly [...]
Manivannan Sethurajan, Eric D. van Hullebusch   +1 more
doaj   +1 more source

Circularity Reinforcement of Critical Raw Materials in Europe: A Case of Niobium

Circular Economy and Sustainability
Critical Raw Materials attract increasing attention due to their depleting reserves and low recyclability. Niobium, one of the most rare and vital elements, is primarily found in Brazil. This research explores the potential impact of Circular Economy (CE)
Theresa von Rennenberg, Yifei Yu, L. Fraccascia, D. Yazan   +3 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Verification of germanium reserves: international experience, economic feasibility and prospects for Ukraine

Мінеральні ресурси України
The European Union classifies germanium as a Critical Raw Material (CRM), which has limited supply and high economic importance. Given the availability of promising deposits and man-made sources of germanium, Ukraine has every chance to strengthen its ...
M. S. Burlutskyy, A. V. Klisko
doaj   +1 more source

Towards a Coherent Trade-Environment Nexus? The EU’s Critical Raw Materials Policy

Journal of World Trade
This article contributes to the debate on the policy coherence of the trade-environment nexus by analysing the recent critical raw materials (CRM) policy of the European Union (EU). Critical raw materials are crucial for the green and digital transitions
Sieglinde Gstöhl, Jonathan Schnock
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Decision-Making for Strategic Raw Materials Using Subjective and Objective Weighting

Alpha Journal of Engineering and Applied Sciences
With the technological advancements, global urbanization, and dynamic socio-economic progress, the demand for strategic raw materials (SRMs) is expected to increase in the coming years, making raw material assessment both inevitable and indispensable ...
Elifcan Göçmen Polat, Erkan Polat
doaj   +1 more source

The European Green Deal, the rush for critical raw materials, and colonialism

One of the core pathways under the European Green Deal to achieving climate neutrality by 2050 is ensuring a secure, resilient and sustainable supply of the critical raw materials needed for a net zero economy.
S. Bogojevic
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source