Results 61 to 70 of about 1,382,332 (278)

Geospatial Data and Deep Learning Expose ESG Risks to Critical Raw Materials Supply: The Case of Lithium

Earth Science, Systems and Society
Disruptions to the global supply chains of critical raw materials (CRM) have the potential to delay or increase the cost of the renewable energy transition.
Christopher J. M. Lawley, Marcus Haynes, B. Chudasama, K. Goodenough, T. Eerola, A. Golev, Steven E. Zhang, Junhyeok Park, É. Lèbre   +8 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Critical Raw Materials Supply: Challenges and Potentialities to Exploit Rare Earth Elements from Siliceous Stones and Extractive Waste

Resources
Critical raw materials (CRMs) supply is a challenge that EU countries have to face, with many thinking about domestic procurement from natural ore deposits and anthropogenic deposits (landfills and extractive waste facilities).
Xinyuan Zhao, Faten Khelifi, Marco Casale, Alessandro Cavallo, E. Padoan, Ke Yang, G. Dino   +6 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the Relevance of Static Cells for Fast Scale‐Up of New Redox Flow Battery Chemistries

Advanced Energy & Sustainability Research
The search for organic electroactive molecules suitable in aqueous organic flow batteries requires great efforts not only from an electrochemical perspective (weeks of testing) but also from an organic synthesis viewpoint.
Lara Lubian, Ruben Rubio‐Presa, Roberto Sanz, Virginia Ruiz, Edgar Ventosa   +4 more
doaj   +1 more source

How to Identify Potentials and Barriers of Raw Materials Recovery from Tailings? Part I: A UNFC-Compliant Screening Approach for Site Selection

Resources, 2021
Mapping the raw material (RM) potential of anthropogenic RMs, such as tailings, requires a comprehensive assessment and classification. However, a simple procedure to quickly screen for potentially viable RMs recovery projects similar to reconnaissance ...
Rudolf Suppes, Soraya Heuss-Aßbichler
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Critical elements for a successful energy transition: A systematic review

Renewable and Sustainable Energy Transition, 2023
The transition to a low-carbon energy future requires large amounts of many raw materials. Some of these materials are deemed critical in terms of their limited availability, concentrated supply chain networks, associated environmental impact, and ...
Mashael Kamran, Marco Raugei, Allan Hutchinson   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Broadening Applicability of the Poor Academic's Method for Reversing Polarity in Redox Flow Cell Cycling

ChemElectroChem
The use of symmetrical cells is becoming popular for the search of new electroactive materials in redox flow batteries. Unfortunately, low‐cost battery cyclers, commonly used for electrochemical battery testing, are not compatible with symmetrical cells ...
Gimena Marin‐Tajadura, Dr. Eduardo Sánchez‐Díez, Dr. Virginia Ruiz, Dr. Edgar Ventosa   +3 more
doaj   +1 more source