Results 31 to 40 of about 52,352 (313)

The USA: the image of our future. Aren’t they?

open access: yesFestival dell'Architettura Magazine, 2023
This article ponders on the role of the United States as the reference point and the model of modern capitalist, consumerist and global culture, anticipating not only what is to come, but also what is already happening, on the rest of the planet ...
Ugo Rossi
doaj   +1 more source

Revealing a Gap in Parametric Architecture’s Address of “Context”

open access: yesBuildings, 2023
“Context” holds a broad meaning in architectural discourse, and its definition and components have evolved over time. A comparison between contemporary parametric design and overall architectural practices reveals a contradictory connotation of context ...
Morteza Hazbei, Carmela Cucuzzella
doaj   +1 more source

Regional service delivery among Pacific Island countries: an assessment [PDF]

open access: yes, 2014
Experience with pooling service delivery among Pacific Island countries has not met the optimistic expectations of advocates, finds this study. Abstract Pacific Island countries face a range of development challenges, including smallness, distance from
Matthew Dornan, Tess Newton Cain
core   +1 more source

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül   +2 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Analysis of local architecture as the basis for sustainable development of the cultural environment on the example of the towns of Biskupice and Zrębice – the municipality of Olsztyn near Częstochowa

open access: yesBudownictwo o Zoptymalizowanym Potencjale Energetycznym, 2020
In the era of where universal architectural forms dominate, there is growing demand for architecture, which, in addition to meeting contemporary functional and technological requirements, also show the identity of its ...
Andrzej Kos
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Not just a "second order" problem in a wider economic crisis: systemic challenges for the global trading system [PDF]

open access: yes, 2009
Reform of the multilateral trade regime is not simply a second order problem within a wider economic crisis. The completion of the Doha Round may be a second order question but the global trade regime faces a series of broader systemic challenges beyond ...
Higgott, Richard A.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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