Results 61 to 70 of about 52,352 (313)

Environmental Resource Management in Borderlands: Evolution from Competing Interests to Common Aversions [PDF]

, 2015
Great enthusiasm is attached to the emergence of cross-border regions (CBRs) as a new institutional arrangement for dealing with local cross-border environmental resource management and other issues that remain too distant from national capitals and/or ...
Belec, John, Buckley, Patrick Henry, Levy, Jason   +2 more
core   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Spaces of Synthesis: Universal Values and Regional Identity in Zlatko Ugljen’s Architecture

Prostor
Zlatko Ugljen’s architecture represents a profound engagement with the interplay between regional identity and universal architectural values. Through an analysis of his most significant works, this paper examines how Ugljen synthesizes traditional ...
Haris Bradić
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Giving Voice to a Building: A Critical Analysis of Adolf Loos’s Landhaus Khuner

ARENA Journal of Architectural Research, 2020
In 1930 Adolf Loos completed two buildings: the (famous, urban) Müller House in Prague and the (not famous, rural) Landhaus Khuner in Payerbach, Lower Austria, some 90 kilometres from Vienna – two designs that could not be more different in appearance ...
Eva Branscome
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Excavating Identity: The Significance of Soil Exhibitions for Understanding Place

Land
Exhibition design, as a powerful medium of communication and interpretation, can reveal the hidden richness and regional identity embedded within the subterranean layers of soil.
Jacqueline McIntosh, Bruno Marques, Philippe Campays, Carles Martinez-Almoyna   +3 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

After Regions: what next for local enterprise partnerships? [PDF]

, 2017
Standing out as an oddity in comparison to the convergence of policy across EU nations whereby the merits of regional apparatus – however defined – for administering development support appear to be accepted, the UK Government has abandoned England’s ...
Bailey D., John Shutt, Lee Pugalis, Pugalis L., Pugalis L., Shutt J., Townsend A. R., Ward M.   +7 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source