Results 61 to 70 of about 4,405,830 (296)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Giving Voice to a Building: A Critical Analysis of Adolf Loos’s Landhaus Khuner

ARENA Journal of Architectural Research, 2020
In 1930 Adolf Loos completed two buildings: the (famous, urban) Müller House in Prague and the (not famous, rural) Landhaus Khuner in Payerbach, Lower Austria, some 90 kilometres from Vienna – two designs that could not be more different in appearance ...
Eva Branscome
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Spaces of Synthesis: Universal Values and Regional Identity in Zlatko Ugljen’s Architecture

Prostor
Zlatko Ugljen’s architecture represents a profound engagement with the interplay between regional identity and universal architectural values. Through an analysis of his most significant works, this paper examines how Ugljen synthesizes traditional ...
Haris Bradić
doaj   +1 more source

Big-Think Regionalism: a critical survey [PDF]

, 2001
Small Think Regionalism focused on the Vinerian question: "Would a nation gain from joining a trade bloc?" Big Think Regionalism considers regionalism's systemic impact on the world trading system, focusing mainly on two questions: "Does spreading regionalism harm world welfare?" and "Does regionalism help or hinder multilateralism?" This paper ...
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Intersecting Itineraries Beyond the Strada Novissima: The Converging Authorship of Critical Regionalism

Architectural Histories, 2016
While the 1980 Venice Biennale is usually understood as the exhibition that crystallised postmodernism as a style of historicist eclecticism, the event also acted as a catalyst for the eventual convergence of alternative architectural sensibilities and ...
Stylianos Giamarelos
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Theoretical and Practical Aspects of Critical Regionalism in the Architectural Oeuvre of Radosav Zeković

Prostor
Radosav Zeković’s (1930-2010) architectural oeuvre constitutes a highly significant corpus within Montenegro’s modernist legacy. This paper examines the approach through which Zeković, operating amid radical socio-political transformations, transposed ...
Ema Alihodžić Jašarović, Sanja Paunović Žarić, Nikola Bajović, Sanja Sekulović   +3 more
doaj   +1 more source