Results 91 to 100 of about 5,804,570 (326)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

Nature Communications
TGF-β-dependent activation of lung fibroblasts is a hallmark of Idiopathic Pulmonary Fibrosis (IPF) which results in excessive collagen deposition and progressive scarring.
Angelo Y. Meliton, Kun Woo D. Shin, Rengül Cetin-Atalay, M. Volkan Atalay, Yufeng Tian, Jennifer C. Houpy Szafran, Takugo Cho, Kaitlyn A. Sun, Parker S. Woods, Obada R. Shamaa, Bohao Chen, Nickolai O. Dulin, Aliya N. Husain, Alexander Muir, Hardik Shah, Gökhan M. Mutlu, Robert B. Hamanaka   +16 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Effect of Scalar Mass in the Absorption and Emission Spectra of Schwarzschild Black Hole

, 2004
Following Sanchez's approach we investigate the effect of scalar mass in the absorption and emission problems of 4d Schwarzschild black hole. The absorption cross sections for arbitrary angular momentum of the scalar field are computed numerically in the
Bekenstein J D, Bekenstein J D, Bekenstein J D, Cvetic M, D K Park, Eylee Jung, Ford L H, Harris C M, Hawking S W, Hawking S W, Hawking S W, Hawking S W, Horowitz G T, Jackiw R, Maldacena J, Maldacena J, Page D N, Peet A W, Persides S, Persides S, Sanchez N, Sanchez N, Sanchez N, Starobinsky A A, Starobinsky A A, Unruh W G   +25 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Electric field in hard superconductors with arbitrary cross section and general critical current law

, 2004
The induced electric field $\vec{E}(\vec{x})$ during magnetic flux entry in superconductors with arbitrary cross section $\Omega$ and general critical current law, has been evaluated by integration along the vortex penetration paths.
Badía-Majós, A., López, C.
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A review and analysis of new Italian law 219/2017: ‘provisions for informed consent and advance directives treatment’

BMC Medical Ethics, 2019
Background In December 2017, Law 219/2017, ‘Provisions for informed consent and advance directives’, was approved in Italy. The law is the culmination of a year-long process and the subject of heated debate throughout Italian society. Contentious issues (
Marco Di Paolo, Federica Gori, Luigi Papi, Emanuela Turillazzi   +3 more
doaj   +1 more source

Airfoil shape for flight at subsonic speeds [PDF]

, 1976
An airfoil is examined that has an upper surface shaped to control flow accelerations and pressure distribution over the upper surface and to prevent separation of the boundary layer due to shock wave formulation at high subsonic speeds well above the ...
Whitcomb, R. T.
core   +1 more source

Statistical inference for 2-type doubly symmetric critical irreducible continuous state and continuous time branching processes with immigration

, 2015
We study asymptotic behavior of conditional least squares estimators for 2-type doubly symmetric critical irreducible continuous state and continuous time branching processes with immigration based on discrete time (low frequency) observations.Comment ...
Barczy, Matyas, Körmendi, Kristóf, Pap, Gyula   +2 more
core   +1 more source