Results 111 to 120 of about 5,804,570 (326)

Validation of Continuous-Energy ENDF/B-VIII.0 ¹⁶O, ⁵⁶Fe, and ^63,65Cu Cross Sections for Nuclear Criticality Safety Applications

, 2020
Alex Shaw, Farzad Rahnema, Andrew Holcomb, Douglas Bowen   +3 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with preserved spirometry and air trapping: a randomized controlled trial

BMC Pulmonary Medicine
Background In tobacco-exposed persons with preserved spirometry (active smoking or secondhand smoke [SHS] exposure), air trapping can identify a subset with worse symptoms and exercise capacity.
Siyang Zeng, Melissa Nishihama, Lemlem Weldemichael, Helen Lozier, Warren M. Gold, Mehrdad Arjomandi   +5 more
doaj   +1 more source

Experimental and Numerical Analysis of Post-Critical States and Damage of Thin-Walled Channel Section Columns Made of Carbon/Epoxy Composite

, 2021
Hubert Dębski, J. Bieniaś
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA

Communications Biology
Cigarette smoke (CS) creates a “cancer field” in the lung that promotes malignant transformation. The molecular changes within this field are not fully characterized.
Asawari Korde, Anuradha Ramaswamy, Seth Anderson, Lei Jin, Jian-ge Zhang, Buqu Hu, Walter V. Velasco, Lixia Diao, Jing Wang, Margaret A. Pisani, Maor Sauler, Daniel J. Boffa, Jonathan T. Puchalski, Xiting Yan, Seyed Javad Moghaddam, Shervin S. Takyar   +15 more
doaj   +1 more source

MUltiparametric Score for Ventilation Discontinuation in Intensive Care Patients: A Protocol for an Observational Study

Methods and Protocols
Background: Mechanical ventilation significantly improves patient survival but is associated with complications, increasing healthcare costs and morbidity.
Iacopo Cappellini, Andrea Cardoni, Lorenzo Campagnola, Guglielmo Consales   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex

ERJ Open Research, 2021
Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander   +20 more
doaj   +1 more source