Results 81 to 90 of about 5,804,570 (326)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Utility of FDG PET/CT for assessment of lung nodules identified during low dose computed tomography screening

BMC Medical Imaging, 2020
Background Many clinical guidelines recommend FDG PET/CT for the evaluation of pulmonary nodules ≥8 mm detected during low dose computed tomography (LDCT) lung cancer screening. However, its added value in this setting requires confirmation. We evaluated
Sarah Hadique, Pranav Jain, Yousaf Hadi, Aneeqah Baig, John E. Parker   +4 more
doaj   +1 more source

The electro production of d* dibaryon

, 1999
$d^*$ dibaryon study is a critical test of hadron interaction models. The electro production cross sections of $ed\to ed^*$ have been calculated based on the meson exchange current model and the cross section around 30 degree of 1 GeV electron in the ...
A. Buchmann, C. W. Wong, Di Qing, F. Wang, F. Wang, Fan Wang, He-ming Sun, J. A. Gómez Tejedor, J. A. Gómez Tejedor, J. A. Gómez Tejedor, J. A. Gómez Tejedor, T. Goldman, T. Goldman, T. W. Donnelly   +13 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Critical central sections of the cube

, 2021
Differs from the published version in minor technical corrections due to degenerate ...
openaire   +4 more sources

CFS: Scaling Metadata Service for Distributed File System via Pruned Scope of Critical Sections [PDF]

, 2023
Yiduo Wang, Yufei Wu, Cheng Li, Pengfei Zheng, Biao Cao, Yan Sun, Fei Zhou, Yinlong Xu, Yao Wang, Guangjun Xie   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Maintained avalanche dynamics during task-induced changes of neuronal activity in nonhuman primates

eLife, 2017
Sensory events, cognitive processing and motor actions correlate with transient changes in neuronal activity. In cortex, these transients form widespread spatiotemporal patterns with largely unknown statistical regularities.
Shan Yu, Tiago L Ribeiro, Christian Meisel, Samantha Chou, Andrew Mitz, Richard Saunders, Dietmar Plenz   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Race and the Inaccuracy of Pulse Oximetry With Hypoxemia in a Pediatric Cardiac ICU

Critical Care Explorations
OBJECTIVES:. To ascertain the potential effects of hypoxemia and race on pulse oximetry in a population of patients, including those for whom hypoxemia is a normal state secondary to intracardiac mixing in an ICU setting. DESIGN:.
Matthew T. Coghill, MD, Mark A. Law, MD, Lece V. Webb, MD, Ahmed Asfari, MD, Santiago Borasino, MD, MPH   +4 more
doaj   +1 more source