Results 91 to 100 of about 219 (184)

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

Unique magnetic transition process demonstrating the effectiveness of bond percolation theory in a quantum magnet

Nature Communications
Like the crystallization of water to ice, magnetic transition occurs at a critical temperature after the slowing down of dynamically fluctuating short-range correlated spins.
Xu-Guang Zheng, Ichihiro Yamauchi, Masato Hagihala, Eiji Nishibori, Tatsuya Kawae, Isao Watanabe, Tomoki Uchiyama, Ying Chen, Chao-Nan Xu   +8 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions

Advanced Science
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, leading to motor and non‐motor symptoms. Early detection before symptom onset is crucial but challenging.
Han Yan, Cole Coughlin, Lee Smolin, Jin Wang   +3 more
doaj   +1 more source

Clinical Variability and Genotype Driven Outcomes in an International Cohort of 14 Pediatric FIG4 Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Biallelic FIG4 variants classically cause distinct conditions characterized by peripheral neuropathy (Charcot‐Marie‐Tooth disease type 4J) or skeletal dysplasia (Yunis‐Varón syndrome). However, central nervous system involvement is increasingly recognized. The prevalence and specific characteristics of movement disorders within FIG4‐
Andrea Gangfuß, Vykuntaraju K. Gowda, Daniel Natera‐de Benito, Pinki Munot, Maria Vanegas, Alejandra Darling, Constanze Reutlinger, Laura Carrera‐Garcia, Gilbert Wunderlich, Heike Kölbel, Burkhard Stüve, David Muhmann, Lucía Monfort Belenguer, Diana‐Gabriela Barca, Viveka Santhosh Reddy C, Varunvenkat M. Srinivasan, Cristina Molina Anguita, Heinz Jungbluth, Hormos Salimi Dafsari, Thomas Rossor, Johann Böhm, Ulrike Schara‐Schmidt, Andreas Roos   +22 more
wiley   +1 more source

Biophysical factors and management practices are key to shaping forest resilience

Nature Communications
Forest management influences key ecosystem services essential for societal well-being. However, how these human management activities affect forest resilience under different environmental conditions remains poorly understood. This study investigates how
Yu Yan, Xingyu Feng, Zhiyong Liu, Zizhao Wang, Zeqin Huang, Yajun Wang, Xin Lan, Juan Chen, Kairong Lin, Xiaohong Chen, Chunyu Dong, Xiaogang He, Giovanni Forzieri   +12 more
doaj   +1 more source

Consciousness as 4-Manifold Painlevé V Dynamics: From Quantum Topology to Classical Gamma Oscillations

Axioms
We propose a novel mathematical framework for understanding consciousness as a dynamical phenomenon governed by nonlinear integrable equations. The central hypothesis identifies conscious state dynamics with the Painlevé VI equation and its confluence ...
Michel Planat
doaj   +1 more source

Associations Between Biomarkers of Alzheimer's Disease and Sleep in Cognitively Unimpaired Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep disturbances have been implicated as a risk factor for developing Alzheimer's disease (AD), but evidence linking plasma AD biomarkers to sleep in cognitively unimpaired individuals remains limited. The present study examined associations between evening, morning, and overnight changes in plasma AD biomarkers and measures of ...
Cornelia Sauter, Hans Dorn, Julian Hellmann‐Regen, Ana Bueno‐Lopez, Verena van Ginneken, Heidi Danker‐Hopfe   +5 more
wiley   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Fast ion relaxation in ITER mediated by Alfvén instabilities

Nuclear Fusion
We address the critical issue for future burning plasmas of whether high-energy fusion products or auxiliary heating-beam ions will be confined for a sufficiently long time to compensate for thermal plasma energy losses.
N.N. Gorelenkov, V.N. Duarte, M.V. Gorelenkova, Zh. Lin, S.D. Pinches   +4 more
doaj   +1 more source