Results 141 to 150 of about 14,468,283 (378)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

O debate da Teoria Crítica sobre a tecnologia

open access: yesCiências Sociais Unisinos, 2017
The article is divided into three parts. In the first part we commented on the central problematizations about the question of technology in authors of the first generation of Critical Theory – namely in Theodor Adorno and Max Horkheimer, and Herbert ...
Ednei de Genaro
doaj  

O "Grande Irmão" e a empresa: indústria cultural, reality shows e espetáculos organizacionais

open access: yesCadernos EBAPE.BR
A motivação para este ensaio relaciona-se à busca de uma via mais direta de comunicação entre pesquisadores descontentes e participantes organizacionais pouco identificados com leituras críticas e mais interessados em render homenagem a certos produtos ...
Marcos Goulart Castelo   +1 more
doaj   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

open access: yesMolecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef   +10 more
wiley   +1 more source

Towards a Theory of Practice: Critical Transdisciplinary Multiliteracies

open access: yes, 2009
About the book: Education institutions and organizations throughout the world are currently being held accountable for achieving and maintaining historically unmatched standards of academic quality and performance.
Albright, James J.   +2 more
core  

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