Results 191 to 200 of about 14,468,283 (378)

The edge visualization metric: Quantifying the improvement of lung SBRT target definition with 4D CBCT

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Four‐dimensional cone‐beam CT (4D CBCT) incorporates oversampling of 3D data to reconstruct multi‐phase CBCT data sets representing distinct phases of the breathing cycle based on a diaphragmatic correlate of respiratory motion. Motion artifacts and blurring can be reduced relative to three‐dimensional cone‐beam (3D CBCT), allowing ...
Colton Baley   +4 more
wiley   +1 more source

Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole‐size spatially fractionated radiotherapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose/objective We propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high‐dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high‐dose spheres.
Joshua Misa   +2 more
wiley   +1 more source

Spinal Cord Abnormalities in Early Pediatric Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Spinal cord lesions and atrophy in the cervical region are common in adult multiple sclerosis (MS) and correlate with disability. Whether similar abnormalities occur in pediatric MS patients is largely unknown. Clinical and MRI evaluations were performed in 38 pediatric MS patients and 13 healthy controls (HC).
Monica Margoni   +7 more
wiley   +1 more source

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee   +19 more
wiley   +1 more source

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