Results 101 to 110 of about 3,194,109 (321)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Review of Race Scholarship and the War on Terror [PDF]

, 2018
The 9/11 terrorist attacks and heavy-handed state and popular response to them stimulated increased scholarship on American Muslims. In the social sciences, this work has focused mainly on Arabs and South Asians, and more recently on African Americans ...
Cainkar, Louise, Selod, Saher
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Interdistrict Choice and Teacher Beliefs: Implications for Educational Expectations, Equity, and Policymaking [PDF]

, 2020
Interdistrict choice, which allows families to choose between schools outside of their districts of residence, is currently serving more students than any other choice program in the United States.
Ambroso, Eric P, Liou, Daniel D., Rotheram-Fuller, Erin   +2 more
core   +1 more source

The Psy-Security-Curriculum ensemble: British Values curriculum policy in English schools [PDF]

, 2018
Framed as being in response to terrorist attacks and concerns about religious bias in some English schools, ‘British Values’ (BV) curriculum policy forms part of the British Government’s Counter-Terrorism and Security Act, 2015.
Ajegbo K., Anderson B., Annamma S. A., Baker K., Ball S. J., BBC, Bhabha H., Butler J., China Mills, Christine Winter, Derrida J., Fanon F., Fitzpatrick P., Froggett L., Gilroy P., Gove M., Hall S., Hesse B., Historical Association, HM Government, HM Government, HM Government., Hussain N., Kundnani A., Lawton D., Mackenzie J. M., Mayes E., Mills C., Nandy A., Ofsted, Osler A., Ozga J., Parehk B., Parker I., Razack S., Rizvi F., Rushdie S., Said E., Santos B. D. S., Tharoor S., Tomlinson S., Tomlinson S., Tomlinson S., Tyler I., Versi M.   +44 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Busing did not fail. We did. : Doublespeak, Whiteness, and the Contradictions of Liberalism in Public Schooling [PDF]

, 2020
Using an interdisciplinary approach and a gear metaphor, I look at why an early 2000s school desegregation program in the Twin Cities was praised as revolutionary, but ended up resulting in greater segregation in the cities.
Dexheimer, Augusta (Gus)
core   +1 more source

WHITE HEAT: racism, under-achievement and white working-class boys [PDF]

, 2000
The article examines students' experience of inner-city education in one of England’s most disadvantaged areas. In particular, we reflect on the views of white working class boys, a group that has recently been identified by policy-makers and the media ...
Gillborn, David, Kirton, Alison
core   +2 more sources