Results 201 to 210 of about 992,630 (344)

Elevating leadership learning: Critical considerations for training, design, and implementation [PDF]

Adrian L. Bitton, Amy C. Barnes
openalex   +1 more source

Strategies for the management and prevention of withdrawal syndrome in critically ill pediatric patients: a systematic review

, 2022
Kassiely Klein, Jéssica Silveira Pereira, Kátia Adriana Lins Jaines Curtinaz, Leonardo Bigolin Jantsch, Neila Santini de Souza, Paulo Roberto Antonaccio Carvalho   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Constraining the impact of chlorine as a neutron absorber in next-gen fast reactor designs. [PDF]

Sci Rep
Hanselman K, Allan IJ, Kuvin SA, Kawano T, Kleedtke N, Lee HY, Paneru SN, Thompson N, Winkelbauer J, Cisneros T, Harper B, Wargon M.   +11 more
europepmc   +1 more source

WEIGHTED CRITICAL PATH ROUTING PROTOCOL FOR MOBILE AD HOC NETWORKS

, 2006
Ihab El Kabary, Amal ElNahas, Said Ghoniemy   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Critical scaling of novelty in the cortex. [PDF]

Nat Commun
Ribeiro TL, Vakili A, Gifford B, Siddiqui R, Sinfuego V, Pajevic S, Plenz D.   +6 more
europepmc   +1 more source

Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources [PDF]

Sarah Rosenbaum, Jenny Moberg, Faith Chesire, Michael Mugisha, Ronald Ssenyonga, Marlyn Ochieng, Clarisse Marie Claudine Simbi, Esther Nakyejwe, Benson Ngatia, Gabriel Rada, Juan Vásquez-Laval, José Damián Garrido, Grace Baguma, Sam Kuloba, Edward Sebukyu, Richard Kabanda, Irene Mwenyango, Tonny Muzaale, Pamela Nandi, Jane Njue, Cyril Oyuga, Florian Rutiyomba, Felecien Rugengamanzi, Joan Murungi, Allen Nsangi, Daniel Semakula, Margaret Kaseje, Nelson K. Sewankambo, Laetitia Nyirazinyoye, Simon Lewin, Andrew D Oxman, Matt Oxman   +31 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation. [PDF]

Front Neural Circuits
Ikeda N, Akita D, Takahashi H.
europepmc   +1 more source