Results 241 to 250 of about 992,630 (344)

Role of anthropogenic mineral circularity in addressing dual challenges of resource supply and waste management in global photovoltaic development. [PDF]

Nat Commun
Yuan X, Song Q, Liu Y, Huang M, Wang Y, Xu Z.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A methodological guideline for consciousness assessment via neural electrophysiological activity. [PDF]

Mil Med Res
Ping AA, Guan LZ, Wang Y, Yang S, Yang C, Hu XQ, Tu YH, Chen H, Li WG, Li XL.   +9 more
europepmc   +1 more source

Application of Blockchain in Procurement and Management of Building Services: A Critical and Systematic Review [PDF]

Thathsarani Hewavitharana, Srinath Perera, Xiaohua Jin, Krisanthi Seneviratne, Keivan Bamdad   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Genetic contributions to brain criticality and its relationship with human cognitive functions. [PDF]

Proc Natl Acad Sci U S A
Xin Y, Cui Y, Yu S, Liu N.
europepmc   +1 more source

Lifting noticing: critical events that mathematics teacher educators notice during coaching cycles [PDF]

Julie M. Amador, Ryan Gillespie, Jennifer Kruger, Ahmad Hanan, Jeffrey Choppin, Kenley Ritter   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

China's progress in developing fourth-generation nuclear reactors. [PDF]

Natl Sci Rev
Poo MM.
europepmc   +1 more source

The climate-energy nexus: a critical review of power grid components, extreme weather, and adaptation measures

Jasmine Garland, Kyri Baker, Ben Livneh
openalex   +1 more source