Results 191 to 200 of about 223,947 (268)

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Use of Human Serum Albumin in Critically Ill Patients: A Narrative Review. [PDF]

J Clin Med
Rubio-Baines I, Camporota L, Camporota L, González-Delgado D, Echarri G, Sala-Trull MC, Montero-López P, Vives M.   +7 more
europepmc   +1 more source

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Performance and Effectiveness of DeepSeek in Assisting Diagnosis of Acutely and Critically Ill Patients: A Single-Center Retrospective Study. [PDF]

MedComm (2020)
Huang T, Zhang J, Tang J, Wang P, Lin F, Tao K, Liu S, Yang Z.   +7 more
europepmc   +1 more source

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Implementation of the kidney protection strategy in critically ill patients with acute kidney injury - a multi-center prospective cohort study. [PDF]

Crit Care
Sadjadi M, Marcello M, Köhler A, Perschinka F, Schauflinger S, Joannidis M, Vadász I, Husain-Syed F, Klop-Riehl M, Pickkers P, Villa G, Nagel T, Bormann E, Booke H, Schöne LM, von Groote T, Mertes MJ, Kellum JA, Strauß C, Zarbock A.   +19 more
europepmc   +1 more source

Low‐Pressure Plasma‐Based Wrinkling of PDMS and Machine Learning‐Driven Property Engineering

Advanced Materials Technologies, EarlyView.
Wrinkled surfaces are well‐suited for controlled surface deformations in the µm range. The key challenge is the relation between the resulting wrinkle features and the necessary process conditions. Machine learning techniques have solved the prediction and inverse design problems for various preparation conditions, opening a precisely controlled ...
Fabian Kopsch, Atmika Bhardwaj, Mirko Nitschke, Ilka Hermes, Andreas Fery, Anett Müller, Marco Werner, André Knapp   +7 more
wiley   +1 more source

Influence of Music on Cortisol Levels in Mechanically Ventilated Critically Ill Patients: A Systematic Review. [PDF]

Nurs Crit Care
Fernández-Álvarez C, Zuazua-Rico D, Mosteiro-Díaz MP, Maestro-González A.   +3 more
europepmc   +1 more source

From Rigid to Soft Robotic Approaches for Neuroendoscopy

Advanced Robotics Research, EarlyView.
Robotic assistance has had minimal impact on deep intraventricular surgeries, where small‐scale, precision, and reduced invasiveness can contribute to improved patient outcomes. Emerging technologies in rigid, soft, and hybrid robotics are reviewed to identify the most promising mechanisms for deep brain navigation in addition to an attempt to identify
Kieran Gilday, Irena Zubak, Andreas Raabe, Josie Hughes   +3 more
wiley   +1 more source

Critically ill patients are not just luggage: The experiences of health workers on the transportation of critically ill patients in hospitals in Tanzania. [PDF]

J Health Serv Res Policy
Maiba J, Mkumbo E, Khalid K, Willows TM, Onyango O, Schell CO, McKnight J, Oliwa J, Baker T.   +8 more
europepmc   +1 more source