Results 251 to 260 of about 592,892 (354)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Less Angst and More Fun: Writing Strategies and Writing Groups for Scholarship. [PDF]

J Grad Med Educ
Sullivan GM, Simpson D, Yarris LM, Deiorio NM, Artino AR.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perceived criticism and depressive symptoms among adults aged 50 years and older: a 17-year population-based cohort study. [PDF]

Transl Psychiatry
Li Y, Zhu L, Yang Y, Zhang C, Zhao H, Shi J, Lai W, Zhou W, Shi G, Wang W, Guo L, Lu C.   +11 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Sensitivity to betrayal and new intimate relationship building in survivors of intimate partner violence. [PDF]

Psychol Psychother
Melin A, Salkovskis PM.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk. [PDF]

J Child Psychol Psychiatry
Curtis M, Colodro-Conde L, Medland SE, Gordon S, Martin NG, Wade TD, Cohen-Woods S.   +6 more
europepmc   +1 more source

Why coding the modality of primary care consultations matters. [PDF]

Br J Gen Pract
Atherton H.
europepmc   +1 more source

The effects of social media criticism against public health institutions on trust, emotions, and social media engagement. [PDF]

Proc Natl Acad Sci U S A
Lee JY.
europepmc   +1 more source