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Critical Care, Critical Data [PDF]

Biomedical Engineering and Computational Biology, 2019
As big data, machine learning, and artificial intelligence continue to penetrate into and transform many facets of our lives, we are witnessing the emergence of these powerful technologies within health care. The use and growth of these technologies has been contingent on the availability of reliable and usable data, a particularly robust resource in ...
David J. Stone, David J. Stone, Leo Anthony Celi, Leo Anthony Celi, Christopher V. Cosgriff, Christopher V. Cosgriff   +5 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Phenomenology as an approach to seeing the aesthetics of ugliness in contemporary art designs

الاكاديمي, 2023
With a descriptive and analytical approach, it discusses the concept of phenomenology as an approach to seeing the aesthetics of ugliness as one of the concepts associated with the aesthetic experience in contemporary art designs, as it is the result of
Tahani Mohammad Nasser AL-Arifi
doaj   +1 more source

Deconfined Criticality Critically Defined [PDF]

Journal of the Physical Society of Japan, 2005
We describe characteristic physical properties of the recently introduced class of deconfined quantum critical points. Using some simple models, we highlight observables which clearly distinguish such critical points from those described by the conventional Landau-Ginzburg-Wilson framework: such a distinction can be made quite precisely even though ...
Leon Balents, Matthew P. A. Fisher, T. Senthil, Subir Sachdev, Ashvin Vishwanath   +4 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Higher criticism for detecting sparse heterogeneous mixtures [PDF]

, 2004
Higher criticism, or second-level significance testing, is a multiplecomparisons concept mentioned in passing by Tukey. It concerns a situation where there are many independent tests of significance and one is interested in rejecting the joint null ...
D. Donoho, Jiashun Jin
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

A psychoanalytic reading of brokenness and loss in Willa Cather’s a lost lady

Cogent Arts & Humanities
Psychoanalysis and literature share an intertwined approach in their exploration of the human mind, emotions and behavior. Some literary works cannot be fully analyzed without deciphering the psychological codes present in them.
Tareq Zuhair
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source