Results 191 to 200 of about 571,246 (252)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
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Journal of Business and Technical Communication, 2008
In the discipline of design, the most common presentation genre is the critique, and the most central aspect of this genre is the feedback. Using a qualitative framework, this article identifies a typology of feedback, compares the frequencies of feedback types between different levels of design studios ranging from novice to expert, and explores what ...
Deanna P. Dannels, Kelly Norris Martin
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In the discipline of design, the most common presentation genre is the critique, and the most central aspect of this genre is the feedback. Using a qualitative framework, this article identifies a typology of feedback, compares the frequencies of feedback types between different levels of design studios ranging from novice to expert, and explores what ...
Deanna P. Dannels, Kelly Norris Martin
openaire +1 more source
King's Theory: A Critique of the Critiques
Nursing Science Quarterly, 1994This article describes Imogene M. King's conceptual framework and theory of goal attainment. The critiques of various nursing scholars reflect a misunderstanding of the intent of the theory and conceptual framework. Major areas of concern of the critics include cultural limitations, patient competence, and lack of specific guidelines to work within the
K F, Carter, L T, Dufour
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Knowledge-Based Systems, 2005
Conversational recommender systems guide users through a product space, alternatively making concrete product suggestions and eliciting the user's feedback. Critiquing is a common form of user feedback, where users provide limited feedback at the feature-level by constraining a feature's value-space.
James Reilly 0001 +3 more
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Conversational recommender systems guide users through a product space, alternatively making concrete product suggestions and eliciting the user's feedback. Critiquing is a common form of user feedback, where users provide limited feedback at the feature-level by constraining a feature's value-space.
James Reilly 0001 +3 more
openaire +2 more sources
Evaluation Review, 1982
In 1974 the results of widely publicized police experiment, the Kansas City Preventive Patrol Experiment (KCPPE), were released. The experiment generated considerable dialogue among police practitioners and researchers alike, who debated such issues as the policy implications of the research findings and the methods employed for obtaining those ...
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In 1974 the results of widely publicized police experiment, the Kansas City Preventive Patrol Experiment (KCPPE), were released. The experiment generated considerable dialogue among police practitioners and researchers alike, who debated such issues as the policy implications of the research findings and the methods employed for obtaining those ...
openaire +1 more source
An Empirical Critique of the Lucas Critique
The Journal of Socio-Economics, 1999Abstract This study provides a quantitative review of the empirical literature on the Lucas critique. Although there is great dissonance concerning the Lucas critique, our meta-analysis revealed how the apparent applicability of the Lucas critique may be attributed to misspecification and the manner in which expectations are treated. When models with
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The Institution of Critique and the Critique of Institutions
Thesis Eleven, 2014My paper argues that Luc Boltanski’s pragmatic sociology makes an important contribution to two central concerns of critical theory: the empirical analysis of the contradictions and conflicts of capitalist societies and the reflexive clarification of the epistemological and normative grounds of critique.
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