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Oral Cromolyn Sodium in Comparison with Elimination Diet in the Irritable Bowel Syndrome, Diarrheic Type Multicenter Study of 428 Patients

Scandinavian Journal of Gastroenterology, 1995
Background: In a significant number of patients affected by the irritable bowel syndrome, an adverse reaction to food is proposed to be a causative factor.
Gabriele Di Lorenzo, V Alvisi, G F Stefanini   +2 more
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Cromolyn Sodium: A Review

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1985
Cromolyn is a white crystalline powder which is poorly absorbed from the gastrointestinal tract. Its therapeutic value lies in its functions as an inhaled or topically applied agent. Cromolyn has been approved in the United States for asthma therapy since 1973.
G G, Shapiro, P, König
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Therapy with Cromolyn Sodium

Annals of Internal Medicine, 1978
Cromolyn is a prototype of a new series of drugs, the pharmacologic activities of which may offer an entirely new approach in the treatment of asthma. Whereas bronchodilator drugs and steroids act primarily at tissue sites to counteract the effects of various toxic mediators released from tissue mast cells, cromolyn prevents the release of such ...
I. LEONARD BERNSTEIN, CHARLES L. JOHNSON, C. S. TED TSE   +2 more
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Cromolyn Sodium

Chest, 1985
Cromolyn sodium is a valuable agent in the pharmacologic management of asthma. In addition to its established effects of inhibiting mediator release, it now appears that it is a useful drug for diminishing the effects of reflex-mediated asthma, nonspecific bronchial hyperreactivity, and diurnal swings of bronchial lability.
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Cromolyn sodium in seasonal allergic conjunctivitis

Journal of Allergy and Clinical Immunology, 1985
A formulation of 2% cromolyn sodium (CS) ophthalmic solution without the preservative, 2-phenylethanol, was compared with placebo in 58 patients with seasonal allergic conjunctivitis. Selection was based on history and positive skin tests. Neither immunotherapy nor use of antihistamines was allowed.
K T, Kray, E N, Squire, W R, Tipton, J C, Selner, J, O'Dea, H S, Nelson   +5 more
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Cromolyn sodium in the management of systemic mastocytosis

Journal of Allergy and Clinical Immunology, 1990
A multicenter, double-blind, placebo-controlled trial of the efficacy of oral cromolyn sodium (200 mg orally four times per day) was conducted in 11 patients with systemic mastocytosis who had been maintained with the drug on an individualized compassionate-need basis.
R F, Horan, A L, Sheffer, K F, Austen
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Sodium Cromoglycate (Cromolyn Sodium)

Drugs, 1974
Therapeutic trials of intranasal sodium cromoglycate have shown it to be of value in some patients with seasonal or perennial allergic rhinitis and in some with perennial rhinitis of unknown cause. Its use usually enables a reduction in antihistamine requirements thus, sodium cromoglycate should be useful in patients made drowsy by antihistamines.
R N, Brogden, T M, Speight, G S, Avery
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Detrimental effect of hypotonic cromolyn sodium

The Journal of Pediatrics, 1992
In a randomized, double-blind, placebo-controlled, crossover study, inhalation of the commercially available nebulized form of cromolyn sodium resulted in a significant decrease in forced midexpiratory flow rate between the 25th and 75th percentile points, equivalent to that observed for distilled water, in children with chronic asthma.
T W, Chin, E, Nussbaum
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Cromolyn sodium in the treatment of children with asthma

Journal of Asthma Research, 1975
We have reported our experience with cromolyn sodium in the management of fifteen children with chronic, intractable asthma. The overall improvement in 80% of children is in accordance with some of the studies reported in the literature. The most significant effect of the drug was in either reducing the dose of steroid needed for management or ...
M, Rao, P, Steiner, M, Victoria
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Cromolyn sodium toxicity studies in primates

Toxicology and Applied Pharmacology, 1981
Abstract The safety evaluation of cromolyn sodium (sodium cromoglycate) included 20 separate toxicity studies in rhesus, cynomolgus and stump-tailed macaques, baboons, and squirrel monkeys. The studies were performed to help evaluate the safety for humans of the use of the compound by dry powder inhalation for the treatment of asthma and by ...
J E, Beach, A M, Blair, A J, Clarke, C T, Bonfield   +3 more
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