Results 111 to 120 of about 2,252,398 (350)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Contamination of seed crops [PDF]

, 1947
A. J. BATEMAN
openalex   +1 more source

Effect of organic, low-input and conventional production systems on yield and diseases in winter barley [PDF]

, 2007
The effect of organic, low-input and conventional management practices on barley yield and disease incidence was assessed in field trials over two years.
Cooper, J. M., Leifert, C., Lueck, L., Schmidt, C. S., Shotton, P. N., Turnbull, C.   +5 more
core  

Weediness of crops in various crop rotations

IOP Conference Series: Earth and Environmental Science, 2019
Abstract Weediness of crops of field crops is examined in various crop rotations. Different types of weeds have unequal effects on crop plants. An expression of this effect is the harmfulness of weeds, which leads to a decrease in yield and a deterioration in the quality of the products.
N. N. Apaeva, A. Y. Efimova, S. A. Zamyatin, S. A. Maksutkin   +3 more
openaire   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Adverse Effects of Ozone Pollution on Net Primary Productivity in the North China Plain

Geophysical Research Letters
Tropospheric ozone significantly damages vegetation and reduces net primary productivity (NPP). We developed a stable linear NPP response model based on accumulated ozone exposure over a threshold of 40 parts per billion (ppb) (AOT40).
X. Long, Y. Han, Q. Y. Wang, X. K. Li, T. Feng, Y. C. Wang, Y. Wang, S. L. Zhang, Y. M. Han, G. H. Li, X. X. Tie, J. J. Cao, Y. Chen   +12 more
doaj   +1 more source

Results of trials with poppy seed (Papaver somniferum) in organic and integrated production technology. [PDF]

, 2010
The influence of organic and integrated management practices on poppy yield, pests and disease incidence was assessed in field trials in 2009. Crop management based on mineral fertilisers application and chemosynthetic pesticides treatment significantly
Dvorak, Petr, Hajkova, Miroslava, Kazda, Jan, Kuchtova, Perla, Plachka, Eva   +4 more
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Increased Phosphorus Losses in the Food System in China and Region‐Specific Mitigation Strategies to Ensure Losses Below Safe Limits

Earth's Future
Sustainable phosphorus (P) resource management is crucial for food security and environmental sustainability. Overuse of P in intensive cropping systems has led to severe eutrophication problems.
Jichen Zhou, Wim deVries, Lin Ma, Xiaoqiang Jiao, Kai Zhang, Yang Lyu, Zed Rengel, Fusuo Zhang, Jianbo Shen   +8 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source