Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Application of Light-emitting Diodes and the Effect of Light Quality on Horticultural Crops: A Review [PDF]
, 2019 Liang Zheng, HE Hua-ming, Weitang Song
openalex +1 more source
Influence of Tillage and Crop Rotations in Organic and Conventional Farming Systems on Soil Organic Matter, Bulk Density and Enzymatic Activities in a Short-Term Field Experiment [PDF]
, 2021 Marco Pittarello +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Thirty years of growing cereal without P and K fertilization [PDF]
, 2008 Over thirty years a significant depletion of P and K in soil occured when the were not given in fertilizers. This caused a reduction in crop yield. An abundant P application exceeding the crop uptake very clearly prevented the yield reduction but did not
Jaakkola, Antti, Yli-Halla, Markku
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Exploring soil microbial 16S
, 2015 Leonardo Machado Pitombo +6 more
openalex +1 more source
Estimation of Grapevine Crop Coefficient Using a Multispectral Camera on an Unmanned Aerial Vehicle [PDF]
, 2021 Deepak Gautam +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source