Results 31 to 40 of about 42,292 (257)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
New crop coefficients developed for high-yield processing tomatoes
California Agriculture, 2006 Processing tomato yields have increased by 53% over the past 35 years, but the current seasonal crop-evapotranspiration requirements that growers use to schedule irrigation are based on 1970s-era data. We updated this data and developed
Blaine Hanson, Donald M. May
doaj +2 more sources
Water requirement and crop coefficients of sorghum in Apodi Plateau
Revista Brasileira de Engenharia Agrícola e Ambiental, 2021 Sorghum is of significant economic importance for Northeastern Brazil, since it exhibits high growth rates in regions with irregular rainfall distribution and high temperatures, and is an alternative to corn, which has greater water requirements. Despite
João G. A. Lima +4 more
doaj +1 more source
Coefficient Of Parentage For Crop Hybridization
, 2007 {"references": ["Chen, Zhengxin and Zhu, Quiming, \"Query construction for user-guided\nknowledge discovery in databases\", Information Sciences 109 (1-4),\n1998, pp. 49-64.", "Fan, Jianhua and Li, Deyi (1998) \"Overview of data mining and\nknowledge discovery\", Journal of Computer Science and Technology.\n13 (4), 1998, pp 348-368.", "H.K Grewal ...
Manpreet Singh +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Italian Journal of Agronomy, 2019 Lowland irrigated rice is the predominant crop produced in the Senegal River Valley characterized by very low annual rainfall, high temperatures, and low relative humidity.
Koffi Djaman +4 more
doaj +1 more source