Results 101 to 110 of about 910,592 (309)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Sunflower crop and climate change: vulnerability, adaptation, and mitigation potential from case-studies in Europe

Oilseeds and fats, crops and lipids, 2017
Climate change is characterized by higher temperatures, elevated atmospheric CO2 concentrations, extreme climatic hazards, and less water available for agriculture. Sunflower, a spring-sown crop often cultivated in southern and eastern regions of Europe,
Debaeke Philippe, Casadebaig Pierre, Flenet Francis, Langlade Nicolas   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Agrivoltaics Crop Yield Modeling

AgriVoltaics Conference Proceedings
Agrivoltaics (APV) combine agriculture and photovoltaic (PV) energy production on the same land and have the potential to provide several synergies for both production systems. Moving towards large-scale commercial implementation, synergies and trade-offs need to be quantified. Various APV designs exist and have been studied in field experiments in the
Felix Schuck, Heike Bach, Erion Bousi, Stephan Schindele   +3 more
openaire   +3 more sources

Substantial Differences in Crop Yield Sensitivities Between Models Call for Functionality‐Based Model Evaluation

Earth's Future
Crop models are often used to project future crop yield under climate and global change and typically show a broad range of outcomes. To understand differences in modeled responses, we analyzed modeled crop yield response types using impact response ...
Christoph Müller, Jonas Jägermeyr, James A. Franke, Alex C. Ruane, Juraj Balkovic, Philippe Ciais, Marie Dury, Pete Falloon, Christian Folberth, Tobias Hank, Munir Hoffmann, R. Cesar Izaurralde, Ingrid Jacquemin, Nikolay Khabarov, Wenfeng Liu, Stefan Olin, Thomas A. M. Pugh, Xuhui Wang, Karina Williams, Florian Zabel, Joshua W. Elliott   +20 more
doaj   +1 more source

INVESTIGATING THE IMPLICATIONS OF MULTI-CROP REVENUE INSURANCE FOR PRODUCER RISK MANAGEMENT [PDF]

This study investigates the potential for alternative multi-crop revenue insurance designs in comparison to single crop yield and revenue insurance designs.
Barnett, Barry J., Coble, Keith H., Miller, J. Corey   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Evaluation of the CERES models in different production regions of the Czech Republic

Plant, Soil and Environment, 2002
The main goal of this work was to calibrate and evaluate the CERES-Barley and CERES-Wheat crop models. The experimental fields used for the model evaluation are situated in three different production regions (maize, sugar beet and potato main growing ...
M. Šťastná, M. Trnka, J. Křen, M. Dubrovský, Z. Žalud   +4 more
doaj   +1 more source