Results 121 to 130 of about 910,592 (309)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Crop Model Parameterisation of Three Important Pearl Millet Varieties for Improved Water Use and Yield Estimation. [PDF]
Plants (Basel), 2022 Ausiku PA +3 more
europepmc +1 more source
Can legume crop residues contribute to sustainable intensification of rainfed rice production in Madagascar? [PDF]
, 2020 Rainfed agriculture on smallholder farms across the tropics is crucial for food security and livelihoods when availability of irrigated land is limited.
Affholder, François +6 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Environmental Research Letters, 2014 In the future, agriculture will need to produce more, from less land, more sustainably. But currently, in many places, actual crop yields are below those attainable.
B A Bryan, D King, G Zhao
doaj +1 more source
Incorporation of machine learning and deep neural network approaches into a remote sensing-integrated crop model for the simulation of rice growth. [PDF]
Sci Rep, 2022 Jeong S, Ko J, Shin T, Yeom JM.
europepmc +1 more source
, 2002 5 slides Provider Notes: Gary Blau's presentation on crop models during Dr. Alan Drysdale's Purdue visit (12/05/2002)
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Environmental Research Letters, 2015 The challenge of estimating the potential impacts of climate change has led to an increasing use of dynamical downscaling to produce fine spatial-scale climate projections for impact assessments. In this work, we analyze if and to what extent the bias in
Johanna Ramarohetra +2 more
doaj +1 more source
Simulating Root Growth as a Function of Soil Strength and Yield With a Field-Scale Crop Model Coupled With a 3D Architectural Root Model. [PDF]
Front Plant Sci, 2022 Seidel SJ +9 more
europepmc +1 more source