Results 71 to 80 of about 22,804,860 (345)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Near Real-Time Biophysical Rice (Oryza sativa L.) Yield Estimation to Support Crop Insurance Implementation in India

Agronomy, 2020
Immediate yield loss information is required to trigger crop insurance payouts, which are important to secure agricultural income stability for millions of smallholder farmers.
Ponraj Arumugam, Abel Chemura, Bernhard Schauberger, Christoph Gornott   +3 more
doaj   +1 more source

Combining multi-source information for crop monitoring [PDF]

, 2008
Time series of optical satellite images acquired at high spatial resolution constitute an important source of information for crop monitoring, in particular for keeping track of crop harvest.
Bégué, Agnès, El Hajj, Mahmoud, Guillaume, Serge, Martiné, Jean-François   +3 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Simulation of the Potential Effect of Meteorological Condition Variations on Forage Production in Native Pastures in the Warm Climate of Colombia

Land
The increasing variability of climatic conditions poses significant challenges for agricultural and livestock systems worldwide. In regions with warm climates, such as northern Colombia, the effects of changing temperature, precipitation, and ...
Eliecer David Díaz-Almanza, José Alejandro Cleves-Leguizamo, Rodrigo Daniel Salgado-Ordosgoitia   +2 more
doaj   +1 more source

Parameterization of crop simulation model “Ceres‐Maize” in Nitra‐Dolná Malanta

Journal of Environmental Engineering and Landscape Management, 2007
Nowadays more than ever production of food depends on reasonable usage of sources. Processes like climate change, climate variability, carbon retention, long‐time food safety are becoming more and more important.
Pavel Samuhel, Bernard Šiška
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Conditioning Machine Learning Models to Adjust Lowbush Blueberry Crop Management to the Local Agroecosystem

Plants, 2020
Agroecosystem conditions limit the productivity of lowbush blueberry. Our objectives were to investigate the effects on berry yield of agroecosystem and crop management variables, then to develop a recommendation system to adjust nutrient and soil ...
Serge-Étienne Parent, Jean Lafond, Maxime C. Paré, Léon Etienne Parent, Noura Ziadi   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Modeling Crop Yield Distributions from Small Samples [PDF]

Accurately modeling crop yield distributions is important for estimation of crop insurance premiums and farm risk-management decisions. A major challenge in the modeling has been due to small sample size.
Smith, Elwin G., Upadhyay, Bharat Mani
core   +1 more source