Results 91 to 100 of about 22,747,399 (346)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The microbiome analysis of ripen grape berries supports the complex etiology of sour rot

Frontiers in Microbiology
Sour rot (SR) is a grapevine disease complex that is not completely understood in its etiology and epidemiology. Recently, SR has received special attention due to its increasing economic importance due to crop losses and reduced wine quality.
Chiara Brischetto, Chiara Brischetto, Vittorio Rossi, Vittorio Rossi, Giorgia Fedele, Giorgia Fedele   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Predicting aphid abundance on winter wheat using suction trap catches

Plant Protection Science, 2020
The relationship between the number of cereal aphids in flight (recorded by a national grid of suction traps in the Czech Republic) and their occurrence on winter wheat (in Prague) was established between 1999-2015.
Alois Honěk, Zdenka Martinková, Marek Brabec, Pavel Saska   +3 more
doaj   +1 more source

Linking Crop Rotation and Fertility Management by a Transition Matrix: Spatial and Dynamic Aspects in Programming of Ecosystem Service [PDF]

This paper deals with crop rotation as a method to pest control and soil fertility from an economic point of view. In the past farmers created complex rotations to benefit from processes like natural pest control, recycling of organics, pollination and ...
Nuppenau, Ernst-August
core   +1 more source

An international collaborative research network helps to design climate robust rice systems [PDF]

, 2009
Rice is the world's most important staple food. Although mainly produced in Asia (91%), it is consumed on all continents and its global importance and consumption is increasing.
Bastiaens, L., Bouman, Bas, Dingkuhn, Michaël, Gaydon, Donald, Hasegawa, Toshihiro, Heinemann, Alexandre, Kiepe, Paul, Lafarge, Tanguy, Luquet, Delphine, Masood, A., Meinke, H., Rodenburg, Jonne, Van Oort, P.A.J., Yan, J., Yin, Xinyou   +14 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Foreword: mycotoxins in a changing world [PDF]

, 2016
This special issue arose because of the changes in the global landscape in relation to the impact and implications of our changing climate on food security and quality, consumer habits, trade and economics, regulations and scientific thinking.
Battilani, Paola, Magan, Naresh, Stroka, Joerg   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Climate change impacts on water for irrigated horticulture in the Vale of Evesham. Final Report [PDF]

, 2007
This project has undertaken a scoping review and assessment of the impacts of climate change on irrigated horticulture in the Vale of Evesham, an area of intense irrigated production located within the Environment Agency’s Warwickshire Avon CAMS ...
Khan, K., Knox, Jerry W., Rodriguez Diaz, J. A., Weatherhead, E. K.   +3 more
core