Results 101 to 110 of about 71,185 (308)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Global potential nitrogen recovery from anaerobic digestion of agricultural residues

Environmental Research Letters
Meeting the anticipated 50% increase in global food demand by 2050 requires a crucial reassessment of agricultural practices, particularly in terms of nitrogen fertilizers inputs.
Pietro Marconi, Lorenzo Rosa
doaj   +1 more source

Segmentation and Proportion Extraction of Crop, Crop Residues, and Soil Using Digital Images and Deep Learning

Agriculture
Conservation tillage involves covering the soil surface with crop residues after harvest, typically through reduced or no-tillage practices. This approach increases the soil organic matter, improves the soil structure, prevents erosion, reduces water ...
Guangfu Gao, Shanxin Zhang, Jianing Shen, Kailong Hu, Jia Tian, Yihan Yao, Qingjiu Tian, Yuanyuan Fu, Haikuan Feng, Yang Liu, Jibo Yue   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Economics of Biomass Fuels for Electricity Production: A Case Study with Crop Residues

In the past, studies on agricultural feedstocks for energy production were motivated by rising fossil fuel prices interpreted by many as caused by resource depletion. However, today's studies are mainly motivated by concerns for climate change and global
McCarl, Bruce A., Maung, Thein A.
core   +1 more source

Estimation of N2O emission factors for soils depending on environmental conditions and crop management

, 2009
Nitrous oxide (N2O) contributes 8% to anthropogenic global warming, of which about one third are direct emissions of agricultural soils. These N2O emissions are often estimated using the default IPCC 2006 emission factor of 1% of the amount of N applied ...
Velthof, G.L., Lesschen, J.P.
core  

A hybrid remote sensing approach to quantifying crop residue burning in the United States [PDF]

, 2008
Crop residue burning is an important land use activity in the United States. Currently, satellite-based burned area methodologies specifically calibrated for crop residue burning are limited.
Trigg, Simon, McCarty, J. L., Loboda, T.
core  

Estimating the contribution of crop residues to soil organic carbon conservation

, 2019
Crop residues contribute to the maintenance of soil organic carbon (SOC) stores, a key component of soil fertility and soil-based climate change mitigation strategies, such as the ‘4 per 1000’ initiative. Residues are also in demand in sectors coupled to
Ioanna Mouratiadou, Ewert, Frank, Frank Ewert, Wallor, Evelyn, Nendel, Claas, Thomas Gaiser, Evelyn Wallor, Mouratiadou, Ioanna, Claas Nendel, Tommaso Stella, Michael Berg-Mohnicke, Berg-Mohnicke, Michael, Stella, Tommaso, Gaiser, Thomas   +13 more
core   +1 more source

Market Assessment of Biomethane from Crop Residues in Ukraine: Techno-Economic Feasibility and Environmental Performance

Energies
Global agriculture generates more than 5 billion tonnes of post-harvest crop residues each year, most of which remain unused for energy production. Within the broader landscape of advanced biomass and waste conversion technologies (thermochemical and ...
Olena Pimenowa, Włodzimierz Rembisz, Liudmyla Udova, Lubov Moldavan, Yan Kapranov, Bożena Iwanowska, Svetlana Sitnicka   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source