Results 71 to 80 of about 2,200,665 (307)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Elicitation of Subjective Crop Yield PDF for DSS Implementation [PDF]
The aim of this research is to establish the persistence of annual crop yield point values subjective estimates, and the coherence and reliability of subjective crop yield probability density functions (PDF) elicited from a series of interviews carried ...
Clop-Gallart, M. Merce +1 more
core
MT-CYP-Net: Multi-task network for pixel-level crop yield prediction under very few samples
International Journal of Applied Earth Observations and GeoinformationAccurate and fine-grained crop yield prediction plays a crucial role in advancing global agriculture. However, the accuracy of pixel-level yield estimation based on satellite remote sensing data has been constrained by the scarcity of ground truth data ...
Shenzhou Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A REVIEW AND EVALUATION OF WEATHER-CROP YIELD MODELS [PDF]
The purpose of this paper is the relatively limited one of reviewing the literature for models which develop specific relationships between climatic variables and crop yields.
Geigel, Joanne M., Sundquist, W. Burt
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
HEDGING CROP RISK WITH YIELD INSURANCE FUTURES AND OPTIONS [PDF]
This paper analyses the optimal hedging decisions for risk-averse producers facing crop risk, assuming crop yield insurance futures and options can be used.
Vermersch, Dominique, Mahul, Olivier
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Shape Persistence in Elicited Subjective Crop Yield Probability Density Functions [PDF]
The shape persistence of a crop yield probability density function (PDF) was studied by using two variants of the Visual Impact Method (VIM) to elicit subjective estimations by farmers.
Clop-Gallart, M. Merce +1 more
core