ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Investigations into cyanobacterial photoacclimation processes address longstanding proposals for improving crop yields. [PDF]
Nat CommunGisriel CJ, Brudvig GW.
europepmc +1 more source
Challenging claimed benefits of soil carbon sequestration for mitigating climate change and increasing crop yields: Heresy or sober realism? [PDF]
Glob Chang Biol, 2023 Powlson DS, Galdos MV.
europepmc +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Correction: 'The heat is on: scaling improvements in photosynthetic thermal tolerance from the leaf to canopy to predict crop yields in a changing climate' (2025), by Cavanagh and Matthews. [PDF]
Philos Trans R Soc Lond B Biol SciCavanagh A.
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Remote sensing-based spatiotemporal assessment of agricultural drought and its impact on crop yields in Punjab, Pakistan. [PDF]
Sci RepRahman G +4 more
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, 1958 Theoretical and practical aspects of the transpiration of crops in the field are discussed and he concludes that the relationship between transpiration and total dry matter production is much less affected by growing conditions than has been supposed.
openaire +1 more source
Arthritis Care &Research, Accepted Article.Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu +2 more
wiley +1 more source
The Role of Nano-Fertilizers in Sustainable Agriculture: Boosting Crop Yields and Enhancing Quality. [PDF]
Plants (Basel)Kekeli MA, Wang Q, Rui Y.
europepmc +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source