Results 31 to 40 of about 37,914 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Distributions of agrobiont lady beetles (Coleoptera: Coccinellidae) among crop and non-crop habitats within an agricultural landscape in east-central South Dakota, USA

Journal of Entomological and Acarological Research
Alternative habitats to predominant corn and soybean fields may help to stem declines of native lady beetles in central North America, but their relative values to native lady beetles have not been directly compared. The goal of this 2-year study was to
Louis Hesler, Eric Beckendorf
doaj   +1 more source

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

The Effect of Water Availability on the Carbon Content of Grain and Above- and Belowground Residues in Common and Einkorn Wheat

Plants
The carbon (C) fixed by crops, which is exported with harvest and retained as postharvest residues in a field, is important for calculating the C balance.
Ivana Raimanova, Pavel Svoboda, Michal Moulik, Jana Wollnerova, Jan Haberle   +4 more
doaj   +1 more source

Agrotool — A system for crop simulation

Archives of Agronomy and Soil Science, 2002
A system for simulation of crop dynamics is described. It includes a dynamic crop model for several cultures and a model shell. The model permits to simulate crop dynamics on the second level of plant productivity. The model shell serves for organization and implementation of series of computer experiments in dialogue regime.
Poluektov, R A, Fintushal, S M, Oparina, I V, Chatskikh, Dmitri, Terleev, V V, Zakharova, E T   +5 more
openaire   +2 more sources

Multimodal Data‐Driven Microstructure Characterization

Advanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang, Santiago Benito, Özge Özgün, Sebastian Weber, Markus Stricker   +4 more
wiley   +1 more source

The role of crop simulation modeling in assessing potential climate change impacts

Agrosystems, Geosciences & Environment
Agriculture is weather dependent, and changes in climate can have a drastic impact on our ability to feed, fuel, and clothe the world's population.
Dennis Timlin, Kirsten Paff, Eunjin Han
doaj   +1 more source

Irrigation Analysis Based on Long-Term Weather Data

Agriculture, 2016
Irrigation management is based upon delivery of water to a crop in the correct amount and time, and the crop’s water need is determined by calculating evapotranspiration (ET) using weather data.
James R. Mahan, Robert J. Lascano
doaj   +1 more source