Results 141 to 150 of about 2,692,904 (342)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Comparing conventional and improved organic vegetable rotations, yields and nitrogen husbandry [PDF]
, 2010 During 2005 to 2009 three approaches to organic vegetable rotations were compared to a conventional rotation in an interdisciplinary project. The organic rotations differed in their reliance on animal manure vs.
Kristensen, Hanne L. +1 more
core
The global burden of pathogens and pests on major food crops
Nature Ecology & Evolution, 2019 S. Savary +5 more
semanticscholar +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Maximizing Forage Yields in Corn Silage Systems with Winter Grains [PDF]
, 2016 Producing sufficient high quality forage on farms is becoming difficult given current economic and environmental pressures. Farmers are looking for strategies to improve yield and quality of their own forage to reduce the financial burden of purchasing ...
Darby, Heather
core +1 more source
Importance of pollinators in changing landscapes for world crops
Proceedings of the Royal Society B: Biological Sciences, 2007 A. Klein +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A model analysis on nitrate leaching under different soil and climate conditions and use of catch crops [PDF]
, 2005 The use of crops and catch crops with deep rooting can strongly improve the possibility of retaining nitrate-N that will otherwise be leached to the deeper soil layers and end up in the surrounding environment.
Pedersen, Anders +2 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source