Results 61 to 70 of about 667,380 (218)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Cross‐sectional area on magnetic resonance images of the semitendinosus tendon is strongly related to the collagen fibril diameter

Journal of Experimental Orthopaedics
Purpose Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction.
Yushin Mizuno, Junsuke Nakase, Tatsuya Ishikawa, Kazuki Asai, Yasushi Takata, Tomoyuki Kanayama, Takuya Sengoku, Noriyuki Ozaki, Hiroyuki Tsuchiya   +8 more
doaj   +1 more source

Fat beyond muscle: Assessing epimuscular fat of the lumbar spine and its association with vertebral level, demographics, BMI, and low back pain

Brain and Spine
Introduction: Epimuscular fat (EF) has rarely been studied in the context of low back pain (LBP). Research question: This study aims to assess the presence and extent of EF in the lumbar muscles and its association with vertebral level in patients with ...
Jacopo A. Vitale, Anne F. Mannion, Daniel Haschtmann, Mario Ropelato, Tamás F. Fekete, Frank S. Kleinstück, Markus Loibl, Tina Haltiner, Fabio Galbusera   +8 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Muscle fibre size and myonuclear positioning in trained and aged humans

Experimental Physiology
Changes in myonuclear architecture and positioning are associated with exercise adaptations and ageing. However, data on the positioning and number of myonuclei following exercise are inconsistent.
Edmund Battey, Yotam Levy, Ross D. Pollock, Jamie N. Pugh, Graeme L. Close, Michaeljohn Kalakoutis, Norman R. Lazarus, Stephen D. R. Harridge, Julien Ochala, Matthew J. Stroud   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Partial Range, Full Gains? The Effect of 8 Weeks of Partial Range of Motion Training at Long Muscle Lengths on Elbow Flexor Hypertrophy and Strength in Trained Individuals

European Journal of Sport Science
We investigated the effects of initial partial range of motion (pROMinitial; 0°–70°) and full range of motion (fROM; 0°–140°) training on elbow flexor hypertrophy and strength in resistance‐trained individuals. Thirteen individuals (males: n = 11, 26.6 ± 
Tim Havers, Niklas Wagner, Steffen Held, Stephan Geisler, Thimo Wiewelhove   +4 more
doaj   +1 more source

Perceptions and awareness of snakebite envenoming in hilly areas of Madikeri: A cross sectional study

MRIMS Journal of Health Sciences
Background: Snake bite is one of the neglected public health problems in many tropical and subtropical countries. Wrong perception and practice of unproven traditional methods about snakes and snakebites may increase mortality due to snakebite envenoming.
Sweta Sinha, Eshwar Sharvanan Udayar, B. C. Narasimha, Ashwini Madeshan, Krishnaveni Marella   +4 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source