Results 81 to 90 of about 773,156 (307)

JugglingSwap: Scriptless Atomic Cross-Chain Swaps

open access: yes, 2020
The blockchain space is changing constantly. New chains are being implemented frequently with different use cases in mind. As more and more types of crypto assets are getting real world value there is an increasing need for blockchain interoperability. Exchange services today are still dominated by central parties which require custody of funds.
Shlomovits, Omer, Leiba, Oded
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Insights into the Design of Congestion Control Protocols for Multi-Hop Wireless Mesh Networks [PDF]

open access: yes, 2009
The widespread deployment of multi-hop wireless mesh networks will depend on the performance seen by the user. Unfortunately, the most predominant transport protocol, TCP, performs poorly over such networks, even leading to starvation in some topologies.
Mossé, Daniel, Qazi, Ihsan Ayyub
core   +2 more sources

Hephaestus: Modelling, Analysis, and Performance Evaluation of Cross-Chain Transactions [PDF]

open access: gold, 2023
Rafael Belchior   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Romania’s competitive advantage within the European Union area [PDF]

open access: yes, 2007
The central idea of the paper emphasizes Romania’s competitive advantages in the EU and there are two analysis levels herein: the correct identification of Romania’s competitive advantages and the oportunities to value them. The paper aims at achieving
Iordache, Emilia   +1 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Dynamics and Control of a Quasi-1D Spin System

open access: yes, 2007
We study experimentally a system comprised of linear chains of spin-1/2 nuclei that provides a test-bed for multi-body dynamics and quantum information processing.
C. Ramanathan   +7 more
core   +1 more source

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