Results 231 to 240 of about 9,045,544 (280)

Abandonment or overreach: the ethical failures of health and social systems and the need for contributory reciprocity. [PDF]

Front Public Health
Baker JR.
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

When high accuracy misleads in literature-derived machine learning for deep eutectic solvent recommendation. [PDF]

RSC Adv
Faraji H, Mendez-Perez JA, Rodríguez-Ramos R, Socas-Rodríguez B, Herrera Herrera AV.   +4 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Psychosocial and clinical determinants of medication adherence among elderly chronic disease patients in China. [PDF]

Front Pharmacol
Zhang Y, Han Y, Sun A, Wu M.
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Design Patterns for the Development and Implementation of Bioacoustic Deep Learning Recognizers. [PDF]

Ecol Evol
Hurd G, Baron R, Whittington J.
europepmc   +1 more source

Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS). [PDF]

Europace
Keene D, Nielsen JC, Nielsen JC, Burri H, Chavez-Gutierrez CA, Deharo JC, Drossart I, Ip JE, Israel CW, Johansen JB, Kosztin A, Lau CP, Levy S, Manlucu J, Marcantoni L, Pujol-Lopez M, Rao A, Starck C, Tolosana JM, Van Erven L, Vogler J, Kaza N.   +21 more
europepmc   +1 more source

Determinants of Rule-Breaking in Adolescence. [PDF]

J Adolesc
Hoyer K, Sijtsema J, Kogler C, van den Bos W, Molleman L.   +4 more
europepmc   +1 more source

Schema validation and evaluation framework for extracted schemas in JSON databases. [PDF]

Sci Rep
Belefqih S, Barchane M, Zellou A, Benlahmar EH.   +3 more
europepmc   +1 more source