Results 61 to 70 of about 877,500 (268)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Systematic Identification of Average ASR Successful Telecommunications Conversations Using the Concept of Dynamic Systems [PDF]

چشم‌انداز مدیریت صنعتی, 2011
Some industrial, social, and managerial issues have their own intricacies and cannot be solved by simple vision and management hypotheses. Dynamic systems thinking is a way of modeling and analyzing the factors of a system and ultimately finding the ...
Nezamodin Faghih, Mohammad Ghafournian
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Damage Detection of Structures for Ambient Loading Based on Cross Correlation Function Amplitude and SVM

Shock and Vibration, 2016
An effective method for the damage detection of skeletal structures which combines the cross correlation function amplitude (CCFA) with the support vector machine (SVM) is presented in this paper. The proposed method consists of two stages.
Lin-sheng Huo, Xu Li, Yeong-Bin Yang, Hong-Nan Li   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Constructions of Golomb Costas arrays and their applications in OFDM systems

Tongxin xuebao, 2013
Theory of structures of Golomb Costas arrays with 1-gap row and 1-gap column was established with the study of the properties and mathematical models of Golomb Costas arrays and their families which are obtained by the cyclic shift method.
Jian-guo YAO, Yu-feng WANG, Wei HENG
doaj  

Method for Detecting Disorder of a Nonlinear Dynamic Plant

Sensors
This paper proposes a new disorder detection method CCF-AE for a scalar dynamic plant based only on its input–output relation using a cross-correlation function and neural network autoencoder.
Xuechun Wang, Vladimir Eliseev
doaj   +1 more source

A Cross-Correlational Analysis between Electroencephalographic and End-Tidal Carbon Dioxide Signals: Methodological Issues in the Presence of Missing Data and Real Data Results

Sensors, 2016
Electroencephalographic (EEG) irreducible artifacts are common and the removal of corrupted segments from the analysis may be required. The present study aims at exploring the effects of different EEG Missing Data Segment (MDS) distributions on cross ...
Maria Sole Morelli, Alberto Giannoni, Claudio Passino, Luigi Landini, Michele Emdin, Nicola Vanello   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Spectral Lags and Characteristic Time Scales of GRBs with Known Redshift

Journal of Advanced Research in Natural and Applied Sciences
In this study, we extracted two key prompt emission parameters, i.e., spectral lags and characteristic time scales, and investigated their potential correlation.
İlham Nasıroğlu, Dilem Göktaş, Eda Sonbaş   +2 more
doaj   +1 more source