Results 81 to 90 of about 496,793 (289)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Fast, greener and scalable direct coupling of organolithium compounds with no additional solvents
Nature Communications, 2016 Cross-coupling reactions typically are carried out under dilute conditions of ethereal solvents. Here, the authors report a method for palladium catalysed cross-coupling of organolithium reagents that avoids the use of any added solvent with reaction ...
Erik B. Pinxterhuis +3 more
doaj +1 more source
$\nu d \to \mu^- \Delta^{++} n$ Reaction and Axial Vector $N-\Delta $ Coupling
, 1998 The reaction $\nu d \to \mu^- \Delta^{++} n$ is studied in the region of low $q^2$ to investigate the effect of deuteron structure and width of the $\Delta$ resonance on the differential cross section. The results are used to extract the axial vector $N-\
A. Bartl +50 more
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction
ProceedingsIntroduction: N-heterocyclic carbenes (NHCs) are considered important preferred auxiliary ligands for transition metals due to their strong σ-donor and weak π-acceptor properties and ease of structural modification in catalyst design.
İrem Bayar, Senem Akkoc
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2017 Several Hiyama cross-coupling reactions of oxasilacycloalkenes and aryl iodides are described that produce trisubstituted Z-styrenes in moderate to excellent yields.
James R. Vyvyan +5 more
doaj +1 more source
Regge phenomenology of pion photoproduction off the nucleon at forward angles
, 2011 We present a Regge model for pion photoproduction which is basically free of parameters within the framework of the s-channel helicity amplitude. We use coupling constants of all exchanged mesons determined from empirical decay widths or from the SU(3 ...
A. Donnachie +7 more
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Molecules, 2015 The present study reports the synthesis of various new derivatives based on 5-aryl-2-bromo-3-hexylthiophene with moderate-to-good yields via a palladium-catalyzed Suzuki cross-coupling reaction. This coupling method involved the reaction of 2,5-dibromo-
Hafiz Mansoor Ikram +8 more
doaj +1 more source