Results 61 to 70 of about 76,876 (265)

Translation, Cross-Cultural Adaptation, and Measurement Properties of the Portuguese Version of the Global Trigger Tool for Adverse Events

Therapeutics and Clinical Risk Management, 2020
Ludmila Pierdevara,1 Ana María Porcel-Gálvez,2 Alexandra Maria Ferreira da Silva,1 Sérgio Barrientos Trigo,3 Margarida Eiras4 1Escuela Internacional de Doctorado, Universidad de Sevilla, Sevilla, Spain; 2Nursing Department, Escuela ...
Pierdevara L, Porcel-Gálvez AM, Ferreira da Silva AM, Barrientos Trigo S, Eiras M   +4 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Turkish Cross‐Cultural Adaptation of Cultural Humility Scale for Nursing Students: A Methodological Research

Nursing Open
Aim In the world today, the wars and ethnic conflicts that emerged due to the expansionist policy brought about by globalisation bring along a multicultural structure formed by different ethnic groups.
Cevriye Yüksel Kaçan, Güven Özkaya
doaj   +1 more source

CROSS-CULTURAL ADAPTATION OF A WOUND ASSESSMENT INSTRUMENT

Cogitare Enfermagem, 2018
Objective: To translate and culturally adapt a chronic wound healing assessment instrument into Brazilian Portuguese. Method: A methodological quantitative study was carried out based on the following stages: translation, translation synthesis, back ...
Elaine Aparecida Rocha Domingues, Maiúme Roana Ferreira de Carvalho, Uiara Aline de Oliveira Kaizer   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cross‐cultural adaption of the computerized assessment of information processing battery (COGNITO) for an Indian longitudinal study on rural elderly

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Introduction Testing cognitive functions in Indians with low literacy and linguistic diversity is challenging. We describe the adaptation process of a comprehensive neurocognitive test battery to suit both literate and illiterate aging rural Indians ...
Ammu Lukose, Rahul Kodihalli Venkatesh, Mino Susan Joseph, Palanimuthu T. Sivakumar, Girish N. Rao, Bangalore N. Gangadhar, Karen Ritchie, Aditi Balakrishnan, Vijayalakshmi Ravindranath, Naren P. Rao   +9 more
doaj   +1 more source

Tradução e adaptação cultural do Charing Cross Venous Ulcer Questionnaire - Brasil Translation and cultural adaptation of Charing Cross Venous Ulcer Questionnaire

Jornal Vascular Brasileiro, 2012
CONTEXTO: A tradução e a adaptação cultural são etapas que permitirão que um instrumento criado em determinado idioma e cultura possa ser usado em outro contexto cultural.
Renata Cardoso Couto, Flávia de Jesus Leal, Guilherme Benjamin Brandão Pitta, Rita de Cássia B. Bezerra, Walmir S. S. Segundo, Tatiana de Mendonça Porto   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source