Results 151 to 160 of about 824,550 (334)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Cross-cultural communication across STEM disciplines

Frontiers in Education
Collaboration across cultures in Science, Technology, Engineering, and Math (STEM) fields has become increasingly common. This means many STEM professionals in US-based companies now work with professionals from other cultures.
Taejung Ma, Anne M. Lucietto
doaj   +1 more source

A situated cultural approach for cross-cultural studies in IS

, 2008
Cultural anthropology seeks to understand the similarities and differences among groups of people in the contemporary world. Although there are many different models of national culture, most IS research has tended to rely almost solely on Hofstede’s ...
Brooks, L, Ali, M
core  

Cultural Orientations Framework (COF) assessment questionnaire in cross-cultural coaching: A cross-validation with Wave Focus Styles [PDF]

, 2010
This paper outlines a cross-validation of the Cultural Orientations Framework assessment questionnaire (COF, Rosinski, 2007; a new tool designed for cross-cultural coaching) with the Saville Consulting Wave Focus Styles questionnaire (Saville Consulting,
McDowall, Almuth, Almuth McDowall, Rojon, C., Rojon, C, Rojon, Céline, Céline Rojon, McDowall, A   +6 more
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Cross-Cultural Health Communication

MediaTor, 2004
Setiap kebudayaan memiliki pandangan yang beragam tentang kesehatan atau penyakit, kehidupan atau kematian. Ada masyarakat yang menganggap penyakit sebagai nasib yang harus diterima secara fatalistik.
Deddy Mulyana
doaj  

Literary Translation as a Translingual Practice: C.D. Balmont and “The Murders in the Rue Morgue” by E.A. Poe

RUDN Journal of Language Studies, Semiotics and Semantics
The authors examine Constantine Balmont’s translation (1911) of Edgar Allan Poe’s short story “The Murders in the Rue Morgue”. The research aims to identify the translator’s main strategies and to interpret this work through the lens of the translingual ...
Nina L. Chulkina, Marta N. Timofeeva
doaj   +1 more source

Cross-platform framing and cross-cultural adaptation : examining elephant conservation in Thailand

, 2012
This case study investigates cross-platform framing process and framing alignment strategies of the world famous elephant conservation NGO. It examines how the intercultural adaptation facilitates the frame transformation against entrenched domesticated ...
Trisha T. C. Lin, Lin, Trisha T. C.
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source