ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Griffiths Scales of Child Development 3rd Edition: normalization for the Brazilian population
Frontiers in PediatricsIntroductionChild development must be carefully evaluated, requiring assessment instruments to assess different areas of development. Griffiths Scales of Child Development 3rd Edition (Griffiths III) is used to assess different areas of development in ...
Amanda Tragueta Ferreira-Vasques +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Botanical Ethnoknowledge Index: a new quantitative assessment method for cross-cultural analysis
Journal of Ethnobiology and EthnomedicineThe scientific accuracy of ethnobotanical study has significantly grown in the past decades due to the adoption of quantitative methods, mainly represented by indices.
Naji Sulaiman
doaj +1 more source
How Time Preferences Differ: Evidence from 45 Countries [PDF]
We present results from the first large-scale international survey on time discounting, conducted in 45 countries. Cross-country variation cannot simply be explained by economic variables such as interest rates or in ation.
Hens, Thorsten +2 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The Janus Face of Cooperation - An Intra- and Cross-Cultural Review [PDF]
This paper introduces a two-sided methodological framework for studies on cooperation based on a new game design. Presented games are continuous prisoner's dilemma games with positive and negative presentations of an identically structured decision
Gari Walkowitz, Sebastian J. Goerg
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Невербальные коммуникативные компоненты в системе межкультурной коммуникации [PDF]
, 2004 The role of non-verbal communicative components in cross-cultural communication is analyzed in the given article. The peculiarities of the adaptation of non-verbal components represented in the English novels in the process of their translation into ...
Солощук, Л.В.
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Medicinal ethnobotany of wild plants: A cross-cultural comparison around Georgia-Turkey border, The Western Lesser Caucasus [PDF]
, 2020 Ceren Kazancı +2 more
openalex +1 more source