Results 151 to 160 of about 1,770,335 (387)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Attitudes of the Youth towards Entrepreneurs and Entrepreneurship: A Cross-cultural Comparison of India and China [PDF]
This study argues that social support is an important enabler in entrepreneurial activity in a country or a region. One untested assumption in policy making on entrepreneurship development has been that all regions are equally desirous of entrepreneurial
Arora, Bhupinder +3 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Transsexualism in Spain: a Cultural and Legal Perspective [PDF]
In this paper I will present an overview of the current legal, social and political situation of transsexual and transgendered people in Spain.
Patr�cia Soley-Beltran
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Human Rights and National Minorities in the United States [PDF]
, 1993 Three human rights myths serve to limit the debate over human rights in the United States and bias our perspective in dealing with the human rights claims of citizens from other countries.
Henry, Charles P.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Identity, Subjectivity and Symptom in Contemporaneous Era [PDF]
Revista Brasileira em Promoção da Saúde, 2003 This article discusses the trio identity, subjectivity and symptom in modern times reflectingabout the individual’s working through and subjectivity processes. This is a bibliography study of psychodynamic orientation.
Yvana Coutinho de Oliveira
doaj
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Presentation Effects in Cross-Cultural Experiments - An Experimental Framework for Comparisons [PDF]
, 2008 This paper investigates the impact of game presentation dependent on ethnical affiliation. Two games representing the same logical and strategical problem are introduced.
Goerg, Sebastian J., Walkowitz, Gari
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Job insecurity : cross-cultural comparison between Germany and China
, 2015 Purpose – The recent economic crisis gave rise to job insecurity and had a seemingly greater effect on western than eastern countries. The purpose of this paper is to examine cross-cultural differences of the influence of job insecurity on employees ...
DE WITTE, Hans +3 more
core +1 more source