Results 181 to 190 of about 1,770,335 (387)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Trust As A Precursor Or Outcome Of Relational Norm Development: A Cross-Cultural Comparison Of US And Hungarian Managers

, 2011
Susan Forquer Gupta, Katalin Eibel-Spanyi, Ernest R. Caddotte, Joesph B. Mosca   +3 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Coparenting in English-Speaking and Chinese Families: A Cross-Cultural Comparison Using the Survey Tool CoPAFS. [PDF]

Children (Basel), 2023
Zhu T, Pruett MK, Alschech J.
europepmc   +1 more source

Motivational Determinants of Physical Activity in Disadvantaged Populations with (Pre)Diabetes: A Cross-Cultural Comparison [PDF]

, 2021
Jeroen De Man, Francis Xavier Kasujja, Peter Delobelle, Kristi Sidney Annerstedt, Helle Mølsted Alvesson, Pilvikki Absetz, Edwin Wouters, Meena Daivadanam, David Guwatudde, Thandi Puoane, Roy Remmen, Hanani Tabana, Josefien van Olmen   +12 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Who is responsible for global road safety? A cross-cultural comparison of Actor Maps.

Accident Analysis and Prevention, 2019
Rich C. McIlroy, K. A. Plant, Md. Shamsul Hoque, Jianping Wu, Gilbert Kokwaro, Vũ Hoài Nam, N. Stanton   +6 more
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A cross-national comparison of violence among young men in China and the UK: psychiatric and cultural explanations [PDF]

, 2017
Jeremy Coid, Junmei Hu, Constantinos Kallis, Ping Yuan, Juying Zhang, Hu Yueying, Laura Bui, Simone Ullrich, Paul Bebbington   +8 more
openalex   +1 more source