Results 71 to 80 of about 160,702 (264)

Chinese and Korean Consumers’ Preferences for Oolong and Black Oolong Teas

Foods
Both China and Korea have significant markets for tea; however, both the availability and preference for oolong and black oolong tea vary across the two markets.
Baihan Su, Jeehyun Lee
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Preuniversity science education in India: Insights and cross cultural comparison

Physical Review Physics Education Research, 2019
A large scale survey reveals that the performance of the Indian preuniversity students in internationally standardized physics tests is intermediate to the American and the Chinese but reveals a disturbing bimodality. Scientific reasoning skills, however,
K. K. Mashood, Vijay A. Singh
doaj   +1 more source

Grammatical Structures in Cross-Cultural Comparisons

Russian journal of linguistics: Vestnik RUDN, 2015
The article discusses how cultural information is embedded at the level of grammar and it treats grammar as inseparable from semantics and pragmatics. The study is done within the approach known as ethnosyntax. The article provides examples of cultural meaning embedded at the level of syntax relying on examples from Russian and English.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Factors Affecting Mobile Users’ Switching Intentions: A Comparative Study between the Brazilian and German Markets [PDF]

BAR: Brazilian Administration Review, 2013
In the competitive wireless market, there are many drivers behind customer defection. Switching barriers, service performance, perceived value in carriers’ offers, satisfaction and other constructs can play a pivotal role in customer switching processes ...
Rodrigo C. Martins, Luis Fernando Hor-Meyll, Jorge Brantes Ferreira   +2 more
doaj  

A cross-cultural study of autistic traits across India, Japan and the UK

Molecular Autism, 2018
Background There is a global need for brief screening instruments that can identify key indicators for autism to support frontline professionals in their referral decision-making. Although a universal set of conditions, there may be subtle differences in
Sophie Carruthers, Emma Kinnaird, Alokananda Rudra, Paula Smith, Carrie Allison, Bonnie Auyeung, Bhismadev Chakrabarti, Akio Wakabayashi, Simon Baron-Cohen, Ioannis Bakolis, Rosa A Hoekstra   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source