T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Thermoelectric Property Mapping for High‐Performance Integrated MgAgSb‐MgCuSb System
Advanced Science, EarlyView.From the property mapping of the MgAgSb–MgCuSb system, both thermoelectric materials and corresponding interface materials are optimized: Ag‐rich compositions provide higher PF and zT, whereas Cu‐rich side yields superior transport properties and low contact resistance.
Jiankang Li +5 more
wiley +1 more source
Political Polarization and Wellbeing: Investigating Potential Intrapersonal Harm From Affective Polarization. [PDF]
Int Rev Soc PsycholMcMurtrie B +4 more
europepmc +1 more source
Dilution Effect for High‐Performance Multiple‐Component Near‐Infrared Organic Photodetectors
Advanced Science, EarlyView.The dilution effect in multi‐component organic photodetector effectively suppresses non‐radiative decay and minimizes dark current, while energy‐level‐offset‐governed electron transfer between acceptors maintains efficient charge transport. This synergistic mechanism collectively enables remarkable device performance, including high detectivity and ...
Zhuang Li +9 more
wiley +1 more source
The bidirectional relationship between depression and perceived social support among college freshmen: evidence from longitudinal and daily diary methods. [PDF]
Front PsycholHan H, Yu X, Li H, Sun N.
europepmc +1 more source
Rapid Steam‐Assisted Temperature Swing Adsorption for Direct Air Capture Using a Rotary Adsorber
Advanced Science, EarlyView.This study presents a direct air capture (DAC) device based on a steam‐regeneration rotary adsorber for high‐purity CO2. Testing of the prototype demonstrates its capability for continuous and stable carbon capture with the potential to achieve ton‐scale.
Junye Wu +6 more
wiley +1 more source
Longitudinal Associations Between Materialism and Problematic Smartphone Use in Adolescence: Within- and Between-Person Effects. [PDF]
Behav Sci (Basel)Dai X +5 more
europepmc +1 more source
Post‐Translational Modifications in Animal Circadian Clocks
Advanced Science, EarlyView.Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
Exploring the dynamic interactions between internet addiction, anxiety, and loneliness in adolescents: a longitudinal cross-lagged panel model. [PDF]
Front PsychiatryWang Y, Gong G.
europepmc +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source