Results 101 to 110 of about 10,356,353 (386)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Volunteering in Cross-National Perspective: Initial Comparisons [PDF]
, 1999 Anheier and Salamon shed some light on volunteering in different parts of the world by exploring the conceptions and patterns of voluntary action cross-nationally.
Anheier, Helmut K., Salamon, Lester M.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Speaking populism: ideational vs. issue-based theories of populism
Frontiers in Political ScienceDebates on the nature and causes of populism persist in the public and among academics. We test two contemporary theories of populism – issue-based and ideational – by exploring their implications for the expression of populist rhetoric among citizens ...
Ethan C. Busby +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
BMC Cancer, 2019 Background Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We evaluated 24/7 Em-EP administration
Charleen Chan Wah Hak +6 more
doaj +1 more source
"The Temporal Welfare State: A Cross-national Comparison" [PDF]
Welfare states contribute to people's well-being in many different ways. Bringing all these contributions under a common metric is tricky. Here we propose doing so through the notion of "temporal autonomy": the freedom to spend one's time as one pleases,
Antti Parpo +2 more
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Identifying sources of error in cross-national questionnaires: Application of an error source typology to cognitive interview data [PDF]
, 2011 This article evaluates a Cross National Error Source Typology that was developed as a tool for making cross-national questionnaire design more effective.
Collins, D. +3 more
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