Results 51 to 60 of about 2,192,442 (266)

Speaking populism: ideational vs. issue-based theories of populism

open access: yesFrontiers in Political Science
Debates on the nature and causes of populism persist in the public and among academics. We test two contemporary theories of populism – issue-based and ideational – by exploring their implications for the expression of populist rhetoric among citizens ...
Ethan C. Busby   +3 more
doaj   +1 more source

Increased shark bite survivability revealed by two centuries of Australian records

open access: yesScientific Reports, 2022
The perceived and real threat of shark bites have significant direct health and indirect economic impacts. Here we assess the changing odds of surviving an unprovoked shark bite using 200 years of Australian records.
James P. Tucker   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Cross-National Interoperability and Enterprise Architecture [PDF]

open access: yesInformatica, 2009
Interoperability is becoming an area with high focus both at national and cross-national level. This paper presents an assessment of the maturity levels of cross-national interoperability activities within the governmental domain in 13 nations.
Gøtze, John   +3 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Understanding the Effects of Crime on Women: Fear and Well-Being in the Context of Diverse Relationships

open access: yesSocial Sciences, 2015
The risk-fear paradox, whereby people who experience the least criminal victimisation report the greatest fear of crime, has been established in the extant literature.
Natalia Hanley, Leah Ruppanner
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Using Card Sorting to Explore the Mental Representation of Energy Transition Pathways Among Laypeople

open access: yesFrontiers in Psychology, 2018
Meeting international emission targets will require major changes in the energy system. This paper addresses the public perception of different pathways to energy transition, and their mental representation in particular.
Rouven Doran   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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