Results 81 to 90 of about 26,032,080 (340)

The Psychology of Online Political Hostility: A Comprehensive, Cross-National Test of the Mismatch Hypothesis

open access: yesAmerican Political Science Review, 2019
Why are online discussions about politics more hostile than offline discussions? A popular answer argues that human psychology is tailored for face-to-face interaction and people’s behavior therefore changes for the worse in impersonal online discussions.
A. Bor, M. Petersen
semanticscholar   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

The cross-national epidemiology of social anxiety disorder: Data from the World Mental Health Survey Initiative

open access: yesBMC Medicine, 2017
BackgroundThere is evidence that social anxiety disorder (SAD) is a prevalent and disabling disorder. However, most of the available data on the epidemiology of this condition originate from high income countries in the West. The World Mental Health (WMH)
Dan J Stein   +33 more
semanticscholar   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Wally and the Major [picture] : national development /

open access: yes, 1957
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Inscription: "Stan Cross 7/270"--In ink, lower right. "5397 Wed Nov 13 National Development"--In ink, right margin; "5320"--In ink, upper right corner; "8"--In pencil, upper left corner.
Cross, Stan, 1888-1977.
core  

Putting ‘political’ back in political trust: an IRT test of the unidimensionality and cross-national equivalence of political trust measures

open access: yesQuality & Quantity: International Journal of Methodology, 2019
Much research intro political trust—its causes, correlates and trends—builds on the twin assumptions that trust in a wide range of political institutions is ultimately an expression of (1) a singular and (2) a cross-nationally equivalent underlying ...
T. V. D. van der Meer, E. Ouattara
semanticscholar   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Trends in overweight and obesity in Lebanon: evidence from two national cross-sectional surveys (1997 and 2009)

open access: yesBMC Public Health, 2012
Background Even though the obesity epidemic continues to grow in various parts of the world, recent reports have highlighted disparities in obesity trends across countries.
Nasreddine Lara   +5 more
doaj   +1 more source

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