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Analysis of cross-over studies with missing data
Statistical Methods in Medical Research, 2015This paper addresses some aspects of the analysis of cross-over trials with missing or incomplete data. A literature review on the topic reveals that many proposals provide correct results under the missing completely at random assumption while only some consider the more general missing at random situation. It is argued that mixed-effects models have
G. Rosenkranz
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Desensitization and Phobias: A Cross-over Study
British Journal of Psychiatry, 1968The results of a comparative trial of desensitization and psychotherapy for phobias have been reported (Gelder, Marks and Wolff, 1967). Desensitization was found to have a rapid and rather specific effect on phobic symptoms, which was followed by improvement in social adjustment.
M G, Gelder, I M, Marks
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Cross-over study of ten tetracycline preparations
European Journal of Clinical Pharmacology, 1973Ten different brands of tetracycline were given to ten medical students in a cross-over study. A single dose of 500 mg was given, blood samples were taken 1,3,6, and 12 h later, and 24 h urines were collected. Peak serum levels of different preparations varied from 2.91±0.45 µg/ml to 4.32±0.31 µg/ml (mean±S.E.M.).
J, Tuomisto, P, Männistö
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A Controlled Cross-over Study of Trimipramine and Amylobarbitone
British Journal of Psychiatry, 1967Chemically, trimipramine has an imino-benzyl nucleus and a side-chain resembling that of methotrimeprazine [5-(3-dimethyl-amino-2-methyl-propyl)-10, 11-dihydrodibenz (b, f,) azepine]. In “double blind” controlled comparisons of trimipramine and imipramine, Salzmann (1965) in 27 hospitalized depressed patients who did not require ECT, found the two ...
J W, Hunter +3 more
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A Cross-Over Study between Hydrallazine and Prazosin
Clinical Science, 19761. In a cross-over study between hydrallazine and prazosin in fifteen patients, also treated with the β-receptor-blocking agent propranolol, 1 mg of prazosin was found to be equipotent with 30 mg of hydrallazine. 2. All patients were known to tolerate hydrallazine.
K, Rasmussen, H A, Jensen
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Cross-Over Factorial Studies with Antihypertensive Drugs
Nephron, 1987In patients with uncomplicated mild to moderate hypertension, studies employing a double-blind randomized cross-over factorial design have been used to obtain more precise estimates of the hypotensive and biochemical effects of individual antihypertensive drugs and of their interactions when used in combination.
Wing, Lmh, Chalmers, JP, West, MJ
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The efficacy of fluoxetine in
BackgroundBurning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS.MethodsIn a 6 ...
Bojana Zoric +5 more
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Randomised cross‐over study of oral appliances for snoring
Clinical Otolaryngology, 2010Clin. Otolaryngol. 2010, 35, 204–209Objectives: To compare a mandibular advancement splint to a control bite raising appliance in the treatment of snoring with or without mild obstructive sleep apnoea syndrome.Design: A prospective two‐treatment randomised cross‐over clinical trial.Setting: Single centre secondary care Dental Hospital.Participants:
Maguire J +5 more
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Hemodialysis / hemofiltration: A report of a controlled cross-over study
The International Journal of Artificial Organs, 1980In 14 stable ESRD patients an ABA cross-over study comparing conventional hemodialysis with post-dilution hemofiltration was performed in order to test the validity of clinical benefits reported for hemofiltration. No effect on blood-pressure could be observed in hypertensive hemofiltration patients when body weight was kept constant.
C A, Baldamus +3 more
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A cross-over study of side of hearing aid provision
Clinical Otolaryngology, 1986No previous study has investigated which ear should be fitted with a hearing aid. Fifty-eight patients with bilateral hearing loss of 25-75 dB HL were sequentially fitted with an ear level hearing aid for 10 weeks in each ear. Patients were then asked their preference for side of fitting, and their reasons for this preference.
I R, Swan, G G, Browning, S, Gatehouse
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