Results 81 to 90 of about 186,023 (249)

Interpretable machine learning model integrating contrast-enhanced CT environmental radiomics and clinicopathological features for predicting postoperative recurrence in lung adenocarcinoma: a retrospective pilot study

Frontiers in Oncology
PurposeThis study aims to develop an interpretable predictive model combining contrast-enhanced CT (CECT) radiomics features with clinicopathological parameters to assess 3-year recurrence risk after surgery for lung adenocarcinoma (LA).MethodsA ...
Song Lin, Song Lin, Yanli Niu, Yanli Niu, Lina Song, Yingjian Ye, Jinfang Yang, Junjie Liu, Xin Zhou, Xin Zhou, Peng An, Peng An   +11 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

No independent association between lymph node metastasis location and recurrence in papillary thyroid carcinoma: a long-term study

Annals of Medicine
Background Whether lymph node metastasis in different anatomical regions of papillary thyroid carcinoma affects recurrence-free survival is controversial.
Chun Huang, Shiying Yang, Zhuolin Dai, Zhaoyu Wan, Jinhang He, Binhao Li, Huili Bai, Xinliang Su   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Quantifying mutual hesitation and identifying kinematic predictors in near-collision avoidance in walking

Scientific Reports
Humans navigate crowded environments by anticipating others’ movements. When such mutual anticipation fails, this may result in collisions or near-collisions.
Kazuyuki Sato, Johannes Keck, Rouwen Cañal-Bruland   +2 more
doaj   +1 more source

Emotional contagion in dyadic online video conferences—empirical evidence based on self-report and facial expression data

Frontiers in Psychology
IntroductionEmotional contagion is an essential and prevalent emotional process in social interaction and comprises the transmission of emotions between two or more individuals.
Anton K. G. Marx, David F. Sachs, Anne C. Frenzel, Martin T. Schweizer   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source