Results 41 to 50 of about 709,384 (266)

Clinical value of high‐frequency ultrasound and serum miR‐92a‐3p in diabetic peripheral neuropathy

Journal of Diabetes Investigation
Aims/Introduction Cross‐sectional area (CSA) by high‐frequency ultrasound (HF‐US) detects morphologic changes in neuropathy. microRNA (miR)‐92a‐3p is linked to diabetes and nerve damage.
Chunmei Qiao, Zhenjiao Liu, Boran Wang, Xin Wang, Zifu Zhao, Hui Wang, Xiaolei Wang   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effects of linear and daily undulating periodized resistance training programs on measures of muscle hypertrophy: a systematic review and meta-analysis [PDF]

PeerJ, 2017
Background Periodization is an important component of resistance training programs. It is meant to improve adherence to the training regimen, allow for constant progression, help in avoiding plateaus, and reduce occurrence and severity of injuries ...
Jozo Grgic, Pavle Mikulic, Hrvoje Podnar, Zeljko Pedisic   +3 more
doaj   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genotypic characterization of cashew (Anacardium occidentale L.) clones using agro‐morphological traits

Plant-Environment Interactions, 2020
High cropping efficiency implies that high yields are obtained from reasonably sized trees. We studied the general and specific combining ability (GCA and SCA) of selected cashew clones of Brazilian (A), Beninese (BE), and Ghanaian (SG) background for ...
Paul K. K. Adu‐Gyamfi, Abraham Akpertey, Michael Barnnor, Atta Ofori, Francis Padi   +4 more
doaj   +1 more source

Reference values for the cross sectional area of normal tibial nerve on high-resolution ultrasonography

Journal of Ultrasonography, 2022
The aim of the study was to establish reference values for the cross-sectional area of the tibial nerve on high-resolution ultrasonography and to investigate the relationship between the cross-sectional area of the tibial nerve and subject’s age, gender,
Singh Kunwar Pal, Kaur Sumanjeet, Arora Vijinder   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ultrasound Characterization of Patellar Tendon in Non-Elite Sport Players with Painful Patellar Tendinopathy: Absolute Values or Relative Ratios? A Pilot Study

Diagnostics, 2020
Imaging findings in patellar tendinopathy are questioned. The aim of this pilot study was to characterize ultrasound measures, by calculating ultrasound ratio and neovascularization of the patellar tendon in non-elite sport players with unilateral ...
José L. Arias-Buría, César Fernández-de-las-Peñas, Jorge Rodríguez-Jiménez, Gustavo Plaza-Manzano, Joshua A. Cleland, Gracia M. Gallego-Sendarrubias, Ibai López-de-Uralde-Villanueva   +6 more
doaj   +1 more source